tetano
Editor, Senior Moderator
J Infect Dis. 2019 May 2. pii: jiz205. doi: 10.1093/infdis/jiz205. [Epub ahead of print]
[h=1]Standard dose intradermal influenza vaccine elicits similar cellular immune responses when compared to intramuscular vaccine in HIV-infected or uninfected men.[/h] Amoah S[SUP]1,[/SUP][SUP]2[/SUP], Mishina M[SUP]1,[/SUP][SUP]2[/SUP], Praphasiri P[SUP]3[/SUP], Cao W[SUP]2[/SUP], Kim JH[SUP]2[/SUP], Liepkalns JS[SUP]2[/SUP], Guo Z[SUP]2[/SUP], Carney PJ[SUP]2[/SUP], Chang JC[SUP]2[/SUP], Fernandez S[SUP]4[/SUP], Garg S[SUP]2[/SUP], Beacham L[SUP]1,[/SUP][SUP]2[/SUP], Holtz TH[SUP]5,[/SUP][SUP]6[/SUP], Curlin ME[SUP]4[/SUP], Dawood F[SUP]2[/SUP], Olsen SJ[SUP]2[/SUP], Gangappa S[SUP]2[/SUP], Stevens J[SUP]2[/SUP], Sambhara S[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] HIV-infected persons are at a higher risk of severe influenza disease. Though we have shown that a standard dose intradermal (ID) versus a standard dose intramuscular (IM) influenza vaccine does not result in differences in hemagglutinin inhibition titers (HI) titers in this population, a comprehensive examination of cell-mediated immune responses remains lacking.
[h=4]METHODS:[/h] Serological, antigen-specific B cell and IL-2, IFN- and TNF-α secreting T cell responses were assessed in 79 HIV-infected and 79 HIV-uninfected men.
[h=4]RESULTS:[/h] The route of vaccination did not affect the IgA and IgG plasmablast or memory B cell response, though these were severely impaired in the CD4 <200 group. The frequencies of IgG memory B cells measured at D28 post-vaccination were highest in the HIV-uninfected group, followed by the CD4 ≥200 and CD4 <200 groups. The route of vaccination did not affect the CD4+ or CD8+ T cell responses measured at various times post-vaccination.
[h=4]CONCLUSIONS:[/h] The route of vaccination had no effect on antibody responses, antibody avidity, T, or B cell responses in HIV-infected or HIV-uninfected subjects. With the serological and cellular immune responses to influenza vaccination in HIV-infected individuals with CD4 <200 being impaired, passive immunization strategies need exploring to protect this population.Clinical trial registration: NCT01538940 https://clinicaltrials.gov/ct2/show/NCT01538940.
Published by Oxford University Press for the Infectious Diseases Society of America 2019. This work is written by (a) US Government employee(s) and is in the public domain in the US.
[h=4]KEYWORDS:[/h] HIV; Influenza; cell-mediated; intradermal; intramuscular; vaccination
PMID: 31045222 DOI: 10.1093/infdis/jiz205
[h=1]Standard dose intradermal influenza vaccine elicits similar cellular immune responses when compared to intramuscular vaccine in HIV-infected or uninfected men.[/h] Amoah S[SUP]1,[/SUP][SUP]2[/SUP], Mishina M[SUP]1,[/SUP][SUP]2[/SUP], Praphasiri P[SUP]3[/SUP], Cao W[SUP]2[/SUP], Kim JH[SUP]2[/SUP], Liepkalns JS[SUP]2[/SUP], Guo Z[SUP]2[/SUP], Carney PJ[SUP]2[/SUP], Chang JC[SUP]2[/SUP], Fernandez S[SUP]4[/SUP], Garg S[SUP]2[/SUP], Beacham L[SUP]1,[/SUP][SUP]2[/SUP], Holtz TH[SUP]5,[/SUP][SUP]6[/SUP], Curlin ME[SUP]4[/SUP], Dawood F[SUP]2[/SUP], Olsen SJ[SUP]2[/SUP], Gangappa S[SUP]2[/SUP], Stevens J[SUP]2[/SUP], Sambhara S[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] HIV-infected persons are at a higher risk of severe influenza disease. Though we have shown that a standard dose intradermal (ID) versus a standard dose intramuscular (IM) influenza vaccine does not result in differences in hemagglutinin inhibition titers (HI) titers in this population, a comprehensive examination of cell-mediated immune responses remains lacking.
[h=4]METHODS:[/h] Serological, antigen-specific B cell and IL-2, IFN- and TNF-α secreting T cell responses were assessed in 79 HIV-infected and 79 HIV-uninfected men.
[h=4]RESULTS:[/h] The route of vaccination did not affect the IgA and IgG plasmablast or memory B cell response, though these were severely impaired in the CD4 <200 group. The frequencies of IgG memory B cells measured at D28 post-vaccination were highest in the HIV-uninfected group, followed by the CD4 ≥200 and CD4 <200 groups. The route of vaccination did not affect the CD4+ or CD8+ T cell responses measured at various times post-vaccination.
[h=4]CONCLUSIONS:[/h] The route of vaccination had no effect on antibody responses, antibody avidity, T, or B cell responses in HIV-infected or HIV-uninfected subjects. With the serological and cellular immune responses to influenza vaccination in HIV-infected individuals with CD4 <200 being impaired, passive immunization strategies need exploring to protect this population.Clinical trial registration: NCT01538940 https://clinicaltrials.gov/ct2/show/NCT01538940.
Published by Oxford University Press for the Infectious Diseases Society of America 2019. This work is written by (a) US Government employee(s) and is in the public domain in the US.
[h=4]KEYWORDS:[/h] HIV; Influenza; cell-mediated; intradermal; intramuscular; vaccination
PMID: 31045222 DOI: 10.1093/infdis/jiz205