tetano
Editor, Senior Moderator
Trends Microbiol. 2019 Oct 6. pii: S0966-842X(19)30220-3. doi: 10.1016/j.tim.2019.08.007. [Epub ahead of print] [h=1]Species-Specific Host-Virus Interactions: Implications for Viral Host Range and Virulence.[/h]
Rothenburg S[SUP]1[/SUP], Brennan G[SUP]2[/SUP].
[h=3]Author information[/h] 1 School of Medicine, University of California Davis, Department of Medical Microbiology and Immunology, Davis, CA 95616, USA. Electronic address: rothenburg@ucdavis.edu. 2 School of Medicine, University of California Davis, Department of Medical Microbiology and Immunology, Davis, CA 95616, USA.
[h=3]Abstract[/h] A growing number of studies indicate that host species-specific and virus strain-specific interactions of viral molecules with the host innate immune system play a pivotal role in determining virus host range and virulence. Because interacting proteins are likely constrained in their evolution, mutations that are selected to improve virus replication in one species may, by chance, alter the ability of a viral antagonist to inhibit immune responses in hosts the virus has not yet encountered. Based on recent findings of host-species interactions of poxvirus, herpesvirus, and influenza virus proteins, we propose a model for viral fitness and host range which considers the full interactome between a specific host species and a virus, resulting from the combination of all interactions, positive and negative, that influence whether a virus can productively infect a cell and cause disease in different hosts.
Copyright ? 2019 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] PKR; herpesvirus, influenza virus; host–pathogen interactions; poxvirus; viral fitness interactome
PMID: 31597598 DOI: 10.1016/j.tim.2019.08.007
Rothenburg S[SUP]1[/SUP], Brennan G[SUP]2[/SUP].
[h=3]Author information[/h] 1 School of Medicine, University of California Davis, Department of Medical Microbiology and Immunology, Davis, CA 95616, USA. Electronic address: rothenburg@ucdavis.edu. 2 School of Medicine, University of California Davis, Department of Medical Microbiology and Immunology, Davis, CA 95616, USA.
[h=3]Abstract[/h] A growing number of studies indicate that host species-specific and virus strain-specific interactions of viral molecules with the host innate immune system play a pivotal role in determining virus host range and virulence. Because interacting proteins are likely constrained in their evolution, mutations that are selected to improve virus replication in one species may, by chance, alter the ability of a viral antagonist to inhibit immune responses in hosts the virus has not yet encountered. Based on recent findings of host-species interactions of poxvirus, herpesvirus, and influenza virus proteins, we propose a model for viral fitness and host range which considers the full interactome between a specific host species and a virus, resulting from the combination of all interactions, positive and negative, that influence whether a virus can productively infect a cell and cause disease in different hosts.
Copyright ? 2019 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] PKR; herpesvirus, influenza virus; host–pathogen interactions; poxvirus; viral fitness interactome
PMID: 31597598 DOI: 10.1016/j.tim.2019.08.007