tetano
Editor, Senior Moderator
fect Genet Evol. 2015 Feb 28. pii: S1567-1348(15)00066-0. doi: 10.1016/j.meegid.2015.02.023. [Epub ahead of print] [h=1]Similarity of currently circulating H1N1 virus with the 2009 pandemic clone: Viability of an imminent pandemic.[/h] Banerjee R[SUP]1[/SUP], Roy A[SUP]2[/SUP], Das S[SUP]3[/SUP], Basak S[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The first influenza pandemic in the 21[SUP]st[/SUP] century commenced in March, 2009 causing nearly 300,000 deaths globally within the first year of the pandemic. In late 2013 and in early 2014, there was gradual increase in the reported case of H1N1 infection and according to World Health Organization (WHO) report, influenza activity increased in several areas of the Southern Hemisphere and was dominated by the H1N1 pandemic strain of 2009. In the present study, a comprehensive comparison of the global amino acid composition and the structural features of all HA gene sequences of H1N1, available in the Flu Database (NCBI), from 1918 to October, 2014 has been performed to trace out the possibility of a further H1N1 pandemic in near future. The results suggest that the increased potential for antibody escape to enhance pathogenicity for the H1N1 samples of 2013 and 2014 could lead to a more severe outbreak in the near future.
Copyright ? 2015 Elsevier B.V. All rights reserved.
[h=4]KEYWORDS:[/h] Evolution; H1N1; Hemagglutinin; Pandemic; Pathogenicity
PMID: 25735729 [PubMed - as supplied by publisher]
[h=3]Author information[/h]
[h=3]Abstract[/h] The first influenza pandemic in the 21[SUP]st[/SUP] century commenced in March, 2009 causing nearly 300,000 deaths globally within the first year of the pandemic. In late 2013 and in early 2014, there was gradual increase in the reported case of H1N1 infection and according to World Health Organization (WHO) report, influenza activity increased in several areas of the Southern Hemisphere and was dominated by the H1N1 pandemic strain of 2009. In the present study, a comprehensive comparison of the global amino acid composition and the structural features of all HA gene sequences of H1N1, available in the Flu Database (NCBI), from 1918 to October, 2014 has been performed to trace out the possibility of a further H1N1 pandemic in near future. The results suggest that the increased potential for antibody escape to enhance pathogenicity for the H1N1 samples of 2013 and 2014 could lead to a more severe outbreak in the near future.
Copyright ? 2015 Elsevier B.V. All rights reserved.
[h=4]KEYWORDS:[/h] Evolution; H1N1; Hemagglutinin; Pandemic; Pathogenicity
PMID: 25735729 [PubMed - as supplied by publisher]