tetano
Editor, Senior Moderator
ACS Appl Mater Interfaces. 2017 Jul 13. doi: 10.1021/acsami.7b07485. [Epub ahead of print]
[h=1]Sialylglycan-Assembled Supra-dots for Ratiometric Probing and Blocking of Human-Infecting Influenza Viruses.[/h] Wang CZ, Han HH, Tang XY, Zhou DM, Wu C, Chen GR, He XP, Tian H.
[h=3]Abstract[/h] The seasonal outbreak of influenza causes significant morbidity and mortality worldwide since a number of influenza virus (IV) strains have been shown to infect and circulate in hu-mans. Development of effective means to timely monitor as well as block IVs is still a chal-lenging task. While conventional fluorescence probes rely on a fluorimetric change upon rec-ognizing IVs, here we developed simple "Supra-dots" that are formed through the aqueous su-pramolecular assembly between a blue-emitting polymer dot and red-emitting sialylglycan probes for the ratiometric detection of IVs. Tuning the F?rster resonance energy-transfer from polymer dots to glycan-probes by selective sialylglycan-virus recognition enables the fluores-cence ratiometric determination of IVs, whereas the presence of unselective, control viruses quenched the fluorescence of the Supra-dots. Meanwhile, we show that the Supra-dots can ef-fectively inhibit the invasion of a human-infecting IV towards a human cell line, thereby mak-ing possible a unique bifunctional, supramolecular probe for influenza theranostics.
PMID: 28703004 DOI: 10.1021/acsami.7b07485
[h=1]Sialylglycan-Assembled Supra-dots for Ratiometric Probing and Blocking of Human-Infecting Influenza Viruses.[/h] Wang CZ, Han HH, Tang XY, Zhou DM, Wu C, Chen GR, He XP, Tian H.
[h=3]Abstract[/h] The seasonal outbreak of influenza causes significant morbidity and mortality worldwide since a number of influenza virus (IV) strains have been shown to infect and circulate in hu-mans. Development of effective means to timely monitor as well as block IVs is still a chal-lenging task. While conventional fluorescence probes rely on a fluorimetric change upon rec-ognizing IVs, here we developed simple "Supra-dots" that are formed through the aqueous su-pramolecular assembly between a blue-emitting polymer dot and red-emitting sialylglycan probes for the ratiometric detection of IVs. Tuning the F?rster resonance energy-transfer from polymer dots to glycan-probes by selective sialylglycan-virus recognition enables the fluores-cence ratiometric determination of IVs, whereas the presence of unselective, control viruses quenched the fluorescence of the Supra-dots. Meanwhile, we show that the Supra-dots can ef-fectively inhibit the invasion of a human-infecting IV towards a human cell line, thereby mak-ing possible a unique bifunctional, supramolecular probe for influenza theranostics.
PMID: 28703004 DOI: 10.1021/acsami.7b07485