tetano
Editor, Senior Moderator
Clin Infect Dis. 2019 Apr 4. pii: ciz264. doi: 10.1093/cid/ciz264. [Epub ahead of print]
[h=1]Severe Illnesses Associated with Outbreaks of Respiratory Syncytial Virus and Influenza in Adults.[/h] Zhou JA[SUP]1[/SUP], Schweinle JE[SUP]1[/SUP], Lichenstein R[SUP]2[/SUP], Walker RE[SUP]1[/SUP], King JC[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Recent reports described the contribution of adult respiratory syncytial virus (RSV) infections to the use of advanced health care resources and death.
[h=4]METHODS:[/h] Data were evaluated over 12 consecutive years (2001-2013) regarding patients ≥ 18 years old, admitted to any of Maryland's 50 acute-care hospitals. We examined RSV and influenza (Flu) surveillance data from the US National Respiratory and Enteric Virus Surveillance System and Centers for Disease Control and Prevention and used this information to define RSV and Flu outbreak periods in the Maryland area. Outbreak periods consisted of consecutive individual weeks whereby at least 10% of RSV and/or Flu diagnostic tests were positive. We examined relationships of RSV and Flu outbreaks to occurrence of four advanced medical outcomes (hospitalization, intensive care unit admission, intubated mechanical ventilation and death) due to medically attended acute respiratory illness (MAARI).
[h=4]RESULTS:[/h] Occurrences of all four MAARI-related hospital advanced medical outcomes were consistently greater for all adult ages during RSV, Flu, and combined RSV/Flu outbreak periods compared to non-outbreak periods, and tended to be greatest in elderly adults aged ≥ 65 years during combined RSV/Flu outbreak periods. Rate ratios for all four MAARI-related advanced medical outcomes ranged from 1.04 to 1.38 during the RSV, Flu or combined RSV/Flu outbreaks compared to the non-outbreak periods, with all 95% lower confidence limits greater than 1.
[h=4]CONCLUSION:[/h] Both RSV and Flu outbreaks were associated with surges in MAARI-related advanced medical outcomes (hospitalization, intensive care unit admission, intubated mechanical ventilation and death) for adults of all ages.
Published by Oxford University Press for the Infectious Diseases Society of America 2019. This work is written by (a) US Government employee(s) and is in the public domain in the US.
[h=4]KEYWORDS:[/h] Medically Attended Acute Respiratory Illness; Death; Hospitalization; Influenza; Intensive Care Unit; Mechanical Ventilation; Respiratory Syncytial Virus
PMID: 30944930 DOI: 10.1093/cid/ciz264
[h=1]Severe Illnesses Associated with Outbreaks of Respiratory Syncytial Virus and Influenza in Adults.[/h] Zhou JA[SUP]1[/SUP], Schweinle JE[SUP]1[/SUP], Lichenstein R[SUP]2[/SUP], Walker RE[SUP]1[/SUP], King JC[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Recent reports described the contribution of adult respiratory syncytial virus (RSV) infections to the use of advanced health care resources and death.
[h=4]METHODS:[/h] Data were evaluated over 12 consecutive years (2001-2013) regarding patients ≥ 18 years old, admitted to any of Maryland's 50 acute-care hospitals. We examined RSV and influenza (Flu) surveillance data from the US National Respiratory and Enteric Virus Surveillance System and Centers for Disease Control and Prevention and used this information to define RSV and Flu outbreak periods in the Maryland area. Outbreak periods consisted of consecutive individual weeks whereby at least 10% of RSV and/or Flu diagnostic tests were positive. We examined relationships of RSV and Flu outbreaks to occurrence of four advanced medical outcomes (hospitalization, intensive care unit admission, intubated mechanical ventilation and death) due to medically attended acute respiratory illness (MAARI).
[h=4]RESULTS:[/h] Occurrences of all four MAARI-related hospital advanced medical outcomes were consistently greater for all adult ages during RSV, Flu, and combined RSV/Flu outbreak periods compared to non-outbreak periods, and tended to be greatest in elderly adults aged ≥ 65 years during combined RSV/Flu outbreak periods. Rate ratios for all four MAARI-related advanced medical outcomes ranged from 1.04 to 1.38 during the RSV, Flu or combined RSV/Flu outbreaks compared to the non-outbreak periods, with all 95% lower confidence limits greater than 1.
[h=4]CONCLUSION:[/h] Both RSV and Flu outbreaks were associated with surges in MAARI-related advanced medical outcomes (hospitalization, intensive care unit admission, intubated mechanical ventilation and death) for adults of all ages.
Published by Oxford University Press for the Infectious Diseases Society of America 2019. This work is written by (a) US Government employee(s) and is in the public domain in the US.
[h=4]KEYWORDS:[/h] Medically Attended Acute Respiratory Illness; Death; Hospitalization; Influenza; Intensive Care Unit; Mechanical Ventilation; Respiratory Syncytial Virus
PMID: 30944930 DOI: 10.1093/cid/ciz264