tetano
Editor, Senior Moderator
Microbiol Immunol. 2011 Jan 19. doi: 10.1111/j.1348-0421.2011.00309.x. [Epub ahead of print]
Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza.
Ohta R, Torii Y, Imai M, Kimura H, Okada N, Ito Y.
Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601 Pediatrics Virology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
Abstract
Anaphylatoxins (C5a, C4a, and C3a) are fragments of activated complement and are leading mediators of the inflammatory response for controlling viral infection. However, an excessive response may increase the severity of infectious diseases. Serum levels of proinflammatory mediators, including cytokines, high-mobility group box 1 and anaphylatoxins in pediatric 2009 H1N1 influenza patients were measured in order to investigate the pathology of this new influenza. The levels of all three anaphylatoxins were significantly enhanced by 2009 H1N1 influenza infection. However, there were no significant differences in anaphylatoxin levels between 2009 H1N1 influenza patients with and without severe complications during the early stage of the disease. The C3a levels dropped significantly during the recovery phase, while there were no significant differences in the C5a and C4a levels between the acute and recovery phases. There was a correlation between C5a and IL-2. C4a was associated with IL-1ra, eotaxin, MCP-1, PDGFbb, and VEGF. C3a was correlated with IL-2 and IFN-γ. Taken together, these findings indicate that complement activation occurs in patients infected with 2009 H1N1 influenza virus and demonstrate that anaphylatoxins are involved in the increased production of proinflammatory mediators in 2009 H1N1 influenza.
? 2011 The Societies and Blackwell Publishing Asia Pty Ltd.
PMID: 21244468 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21244468
Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza.
Ohta R, Torii Y, Imai M, Kimura H, Okada N, Ito Y.
Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601 Pediatrics Virology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
Abstract
Anaphylatoxins (C5a, C4a, and C3a) are fragments of activated complement and are leading mediators of the inflammatory response for controlling viral infection. However, an excessive response may increase the severity of infectious diseases. Serum levels of proinflammatory mediators, including cytokines, high-mobility group box 1 and anaphylatoxins in pediatric 2009 H1N1 influenza patients were measured in order to investigate the pathology of this new influenza. The levels of all three anaphylatoxins were significantly enhanced by 2009 H1N1 influenza infection. However, there were no significant differences in anaphylatoxin levels between 2009 H1N1 influenza patients with and without severe complications during the early stage of the disease. The C3a levels dropped significantly during the recovery phase, while there were no significant differences in the C5a and C4a levels between the acute and recovery phases. There was a correlation between C5a and IL-2. C4a was associated with IL-1ra, eotaxin, MCP-1, PDGFbb, and VEGF. C3a was correlated with IL-2 and IFN-γ. Taken together, these findings indicate that complement activation occurs in patients infected with 2009 H1N1 influenza virus and demonstrate that anaphylatoxins are involved in the increased production of proinflammatory mediators in 2009 H1N1 influenza.
? 2011 The Societies and Blackwell Publishing Asia Pty Ltd.
PMID: 21244468 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21244468