tetano
Editor, Senior Moderator
Clin Vaccine Immunol. 2011 Feb 23. [Epub ahead of print]
Sero-prevalence of Pandemic (H1N1) 2009 Influenza A Virus among Schoolchildren and Their Parents in Tokyo, Japan.
Iwatsuki-Horimoto K, Horimoto T, Tamura D, Kiso M, Kawakami E, Hatakeyama S, Ebihara Y, Koibuchi T, Fujii T, Takahashi K, Shimojima M, Sakai-Tagawa Y, Ito M, Sakabe S, Iwasa A, Takahashi K, Ishii T, Gorai T, Tsuji K, Iwamoto A, Kawaoka Y.
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Pediatric Hematology/Oncology, Research Hospital, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Division of Infectious Diseases, Advanced Clinical Research Center, Institute of University of Tokyo, Tokyo 108-8639, Japan; Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, Osaka 537-0025, Japan; Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, 108-8639, Japan; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53711, USA; ERATO Infection-Induced Host Responses Project, Saitama 332-0012, Japan.
Abstract
Since its emergence, the 2009 pandemic H1N1 virus has spread rapidly throughout the world. Previously, we reported that most individuals born after 1920 do not have cross-reactive virus neutralizing antibodies against pandemic (H1N1) 2009 virus, indicating that they were immunologically na?ve to the pandemic virus prior to its emergence. This finding provided us with an excellent opportunity for a sero-epidemiological investigation of the transmission mode of the pandemic virus in the community. To gain insight into its transmission within communities, we performed a sero-survey for pandemic virus infection in schoolchildren and their parents at an elementary school in Tokyo, Japan. We observed a high prevalence of neutralizing antibodies to the pandemic virus in the children at this school, although the percentage of children positive for the neutralizing antibodies varied among classrooms. While a much lower prevalence was observed among parents, sero-positivity among parents correlated with that of their schoolchildren. Moreover, many adults appeared to have experienced asymptomatic infection with the pandemic virus. These data suggest that the pandemic virus was readily transmitted among schoolchildren in elementary schools and that it also transmitted from schoolchildren to their parents.
PMID: 21346056 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21346056
Sero-prevalence of Pandemic (H1N1) 2009 Influenza A Virus among Schoolchildren and Their Parents in Tokyo, Japan.
Iwatsuki-Horimoto K, Horimoto T, Tamura D, Kiso M, Kawakami E, Hatakeyama S, Ebihara Y, Koibuchi T, Fujii T, Takahashi K, Shimojima M, Sakai-Tagawa Y, Ito M, Sakabe S, Iwasa A, Takahashi K, Ishii T, Gorai T, Tsuji K, Iwamoto A, Kawaoka Y.
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Pediatric Hematology/Oncology, Research Hospital, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Division of Infectious Diseases, Advanced Clinical Research Center, Institute of University of Tokyo, Tokyo 108-8639, Japan; Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, Osaka 537-0025, Japan; Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, 108-8639, Japan; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53711, USA; ERATO Infection-Induced Host Responses Project, Saitama 332-0012, Japan.
Abstract
Since its emergence, the 2009 pandemic H1N1 virus has spread rapidly throughout the world. Previously, we reported that most individuals born after 1920 do not have cross-reactive virus neutralizing antibodies against pandemic (H1N1) 2009 virus, indicating that they were immunologically na?ve to the pandemic virus prior to its emergence. This finding provided us with an excellent opportunity for a sero-epidemiological investigation of the transmission mode of the pandemic virus in the community. To gain insight into its transmission within communities, we performed a sero-survey for pandemic virus infection in schoolchildren and their parents at an elementary school in Tokyo, Japan. We observed a high prevalence of neutralizing antibodies to the pandemic virus in the children at this school, although the percentage of children positive for the neutralizing antibodies varied among classrooms. While a much lower prevalence was observed among parents, sero-positivity among parents correlated with that of their schoolchildren. Moreover, many adults appeared to have experienced asymptomatic infection with the pandemic virus. These data suggest that the pandemic virus was readily transmitted among schoolchildren in elementary schools and that it also transmitted from schoolchildren to their parents.
PMID: 21346056 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21346056