tetano
Editor, Senior Moderator
Osong Public Health Res Perspect. 2011 Dec;2(3):210-5. doi: 10.1016/j.phrp.2011.11.048.
Sensitivity Analysis of the Parameters of Korea's Pandemic Influenza Preparedness Plan.
Chu C, Lee J, Choi DH, Youn SK, Lee JK.
Source
Division of Epidemic Intelligence Service, Korea Centers for Disease Control and Prevention, Osong, Korea.
Abstract
OBJECTIVES:
Our aim was to evaluate Korea's Pandemic Influenza Preparedness Plan.
METHODS:
We conducted a sensitivity analysis on the expected number of outpatients and hospital bed occupancy, with 1,000,000 parameter combinations, in a situation of pandemic influenza, using the mathematical simulation program InfluSim.
RESULTS:
Given the available resources in Korea, antiviral treatment and social distancing must be combined to reduce the number of outpatients and hospitalizations sufficiently; any single intervention is not enough. The antiviral stockpile of 4-6% is sufficient for the expected eligible number of cases to be treated. However, the eligible number assumed (30% for severe cases and 26% for extremely severe cases) is very low compared to the corresponding number in European countries, where up to 90% of the population are assumed to be eligible for antiviral treatment.
CONCLUSIONS:
A combination of antiviral treatment and social distancing can mitigate a pandemic, but will only bring it under control for the most optimistic parameter combinations.
KEYWORDS:
influenza pandemic, preparedness planning, sensitivity analysis
PMID:
24159475
[PubMed]
http://www.ncbi.nlm.nih.gov/pubmed/24159475
Sensitivity Analysis of the Parameters of Korea's Pandemic Influenza Preparedness Plan.
Chu C, Lee J, Choi DH, Youn SK, Lee JK.
Source
Division of Epidemic Intelligence Service, Korea Centers for Disease Control and Prevention, Osong, Korea.
Abstract
OBJECTIVES:
Our aim was to evaluate Korea's Pandemic Influenza Preparedness Plan.
METHODS:
We conducted a sensitivity analysis on the expected number of outpatients and hospital bed occupancy, with 1,000,000 parameter combinations, in a situation of pandemic influenza, using the mathematical simulation program InfluSim.
RESULTS:
Given the available resources in Korea, antiviral treatment and social distancing must be combined to reduce the number of outpatients and hospitalizations sufficiently; any single intervention is not enough. The antiviral stockpile of 4-6% is sufficient for the expected eligible number of cases to be treated. However, the eligible number assumed (30% for severe cases and 26% for extremely severe cases) is very low compared to the corresponding number in European countries, where up to 90% of the population are assumed to be eligible for antiviral treatment.
CONCLUSIONS:
A combination of antiviral treatment and social distancing can mitigate a pandemic, but will only bring it under control for the most optimistic parameter combinations.
KEYWORDS:
influenza pandemic, preparedness planning, sensitivity analysis
PMID:
24159475
[PubMed]
http://www.ncbi.nlm.nih.gov/pubmed/24159475