Giuseppe
Emeritus
Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus -- Xu et al. 328 (5976): 357 (Science, abstract, edited)
[Source: Science, <cite cite="http://www.sciencemag.org/cgi/content/abstract/328/5976/357">Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus -- Xu et al. 328 (5976): 357 -- Science</cite>. Edited.]
Originally published in Science Express on 25 March 2010
Science 16 April 2010:Vol. 328. no. 5976, pp. 357 - 360
DOI: 10.1126/science.1186430
Reports
Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus
Rui Xu,1,* Damian C. Ekiert,1,* Jens C. Krause,2 Rong Hai,3 James E. Crowe, Jr.,2 Ian A. Wilson1,4,
The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure, particularly within the Sa antigenic site, is extremely similar to those of human H1N1 viruses circulating early in the 20th century. The cocrystal structure of the 1918 hemagglutinin with 2D1, an antibody from a survivor of the 1918 Spanish flu that neutralizes both 1918 and 2009 H1N1 viruses, reveals an epitope that is conserved in both pandemic viruses. Thus, antigenic similarity between the 2009 and 1918-like viruses provides an explanation for the age-related immunity to the current influenza pandemic.
1 Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
2 Departments of Pediatrics and Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
3 Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA.
4 Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
* These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail: wilson@scripps.edu
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[Source: Science, <cite cite="http://www.sciencemag.org/cgi/content/abstract/328/5976/357">Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus -- Xu et al. 328 (5976): 357 -- Science</cite>. Edited.]
Originally published in Science Express on 25 March 2010
Science 16 April 2010:Vol. 328. no. 5976, pp. 357 - 360
DOI: 10.1126/science.1186430
Reports
Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus
Rui Xu,1,* Damian C. Ekiert,1,* Jens C. Krause,2 Rong Hai,3 James E. Crowe, Jr.,2 Ian A. Wilson1,4,
The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure, particularly within the Sa antigenic site, is extremely similar to those of human H1N1 viruses circulating early in the 20th century. The cocrystal structure of the 1918 hemagglutinin with 2D1, an antibody from a survivor of the 1918 Spanish flu that neutralizes both 1918 and 2009 H1N1 viruses, reveals an epitope that is conserved in both pandemic viruses. Thus, antigenic similarity between the 2009 and 1918-like viruses provides an explanation for the age-related immunity to the current influenza pandemic.
1 Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
2 Departments of Pediatrics and Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
3 Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA.
4 Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
* These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail: wilson@scripps.edu
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