tetano
Editor, Senior Moderator
Science
. 2021 Apr 12;eabf6648.
doi: 10.1126/science.abf6648. Online ahead of print.
Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues
Fan Yang[SUP] 1 [/SUP], Sandra C A Nielsen[SUP] 2 [/SUP], Ramona A Hoh[SUP] 2 [/SUP], Katharina R?ltgen[SUP] 2 [/SUP], Oliver Fabian Wirz[SUP] 2 [/SUP], Emily Haraguchi[SUP] 2 [/SUP], Grace H Jean[SUP] 2 [/SUP], Ji-Yeun Lee[SUP] 2 [/SUP], Tho D Pham[SUP] 2 3 [/SUP], Katherine J L Jackson[SUP] 4 [/SUP], Krishna M Roskin[SUP] 5 6 7 [/SUP], Yi Liu[SUP] 8 [/SUP], Khoa Nguyen[SUP] 2 [/SUP], Robert S Ohgami[SUP] 9 [/SUP], Eleanor M Osborne[SUP] 10 [/SUP], Kari C Nadeau[SUP] 11 12 [/SUP], Claus U Niemann[SUP] 13 14 [/SUP], Julie Parsonnet[SUP] 15 16 [/SUP], Scott D Boyd[SUP] 1 11 [/SUP]
Affiliations
Abstract
Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells, which encode humoral immune memory. We evaluated convergent antigen-specific antibody genes of similar sequences shared between individuals in pediatric and adult blood, and deceased organ donor tissues. B cell memory varied for different pathogens. Polysaccharide antigen-specific clones were not exclusive to the spleen. Adults had higher clone frequencies and greater class-switching in lymphoid tissues than blood, while pediatric blood had abundant class-switched convergent clones. Consistent with reported serology, pre-pandemic children had class-switched convergent clones to SARS-CoV-2 with weak cross-reactivity to other coronaviruses, while adult blood or tissues showed few such clones. The results highlight the prominence of early childhood B cell clonal expansions and cross-reactivity for future responses to novel pathogens.
. 2021 Apr 12;eabf6648.
doi: 10.1126/science.abf6648. Online ahead of print.
Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues
Fan Yang[SUP] 1 [/SUP], Sandra C A Nielsen[SUP] 2 [/SUP], Ramona A Hoh[SUP] 2 [/SUP], Katharina R?ltgen[SUP] 2 [/SUP], Oliver Fabian Wirz[SUP] 2 [/SUP], Emily Haraguchi[SUP] 2 [/SUP], Grace H Jean[SUP] 2 [/SUP], Ji-Yeun Lee[SUP] 2 [/SUP], Tho D Pham[SUP] 2 3 [/SUP], Katherine J L Jackson[SUP] 4 [/SUP], Krishna M Roskin[SUP] 5 6 7 [/SUP], Yi Liu[SUP] 8 [/SUP], Khoa Nguyen[SUP] 2 [/SUP], Robert S Ohgami[SUP] 9 [/SUP], Eleanor M Osborne[SUP] 10 [/SUP], Kari C Nadeau[SUP] 11 12 [/SUP], Claus U Niemann[SUP] 13 14 [/SUP], Julie Parsonnet[SUP] 15 16 [/SUP], Scott D Boyd[SUP] 1 11 [/SUP]
Affiliations
- PMID: 33846272
- DOI: 10.1126/science.abf6648
Abstract
Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells, which encode humoral immune memory. We evaluated convergent antigen-specific antibody genes of similar sequences shared between individuals in pediatric and adult blood, and deceased organ donor tissues. B cell memory varied for different pathogens. Polysaccharide antigen-specific clones were not exclusive to the spleen. Adults had higher clone frequencies and greater class-switching in lymphoid tissues than blood, while pediatric blood had abundant class-switched convergent clones. Consistent with reported serology, pre-pandemic children had class-switched convergent clones to SARS-CoV-2 with weak cross-reactivity to other coronaviruses, while adult blood or tissues showed few such clones. The results highlight the prominence of early childhood B cell clonal expansions and cross-reactivity for future responses to novel pathogens.