tetano
Editor, Senior Moderator
Science
. 2024 Dec 20;386(6728):1389-1395.
doi: 10.1126/science.adi2396. Epub 2024 Dec 19. Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses
Vamsee Mallajosyula[SUP] 1 [/SUP], Saborni Chakraborty[SUP] 1 2 [/SUP], Elsa Sola[SUP] 1 [/SUP], Ryan Furuichi Fong[SUP] 1 [/SUP], Vishnu Shankar[SUP] 3 [/SUP], Fei Gao[SUP] 1 [/SUP], Allison R Burrell[SUP] 4 [/SUP], Neha Gupta[SUP] 1 [/SUP], Lisa E Wagar[SUP] 1 5 [/SUP], Paul S Mischel[SUP] 6 7 [/SUP], Robson Capasso[SUP] 8 [/SUP], Mary A Staat[SUP] 4 [/SUP], Yueh-Hsiu Chien[SUP] 1 9 [/SUP], Cornelia L Dekker[SUP] 1 10 [/SUP], Taia T Wang[SUP] 1 2 [/SUP], Mark M Davis[SUP] 1 9 11 [/SUP]
Affiliations
The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined. However, most individuals exhibit a more robust response to one of these strains and thus are vulnerable to infection by others. By studying a monozygotic twin cohort, we found that although prior exposure is a factor, host genetics are a stronger driver of subtype bias to influenza viral strains. We found that covalent coupling of heterologous hemagglutinin (HA) from different viral strains could largely eliminate subtype bias in an animal model and in a human tonsil organoid system. We proposed that coupling of heterologous antigens improves antibody responses across influenza strains by broadening T cell help, and we found that using this approach substantially improved the antibody response to avian influenza HA.
. 2024 Dec 20;386(6728):1389-1395.
doi: 10.1126/science.adi2396. Epub 2024 Dec 19. Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses
Vamsee Mallajosyula[SUP] 1 [/SUP], Saborni Chakraborty[SUP] 1 2 [/SUP], Elsa Sola[SUP] 1 [/SUP], Ryan Furuichi Fong[SUP] 1 [/SUP], Vishnu Shankar[SUP] 3 [/SUP], Fei Gao[SUP] 1 [/SUP], Allison R Burrell[SUP] 4 [/SUP], Neha Gupta[SUP] 1 [/SUP], Lisa E Wagar[SUP] 1 5 [/SUP], Paul S Mischel[SUP] 6 7 [/SUP], Robson Capasso[SUP] 8 [/SUP], Mary A Staat[SUP] 4 [/SUP], Yueh-Hsiu Chien[SUP] 1 9 [/SUP], Cornelia L Dekker[SUP] 1 10 [/SUP], Taia T Wang[SUP] 1 2 [/SUP], Mark M Davis[SUP] 1 9 11 [/SUP]
Affiliations
- PMID: 39700292
- DOI: 10.1126/science.adi2396
The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined. However, most individuals exhibit a more robust response to one of these strains and thus are vulnerable to infection by others. By studying a monozygotic twin cohort, we found that although prior exposure is a factor, host genetics are a stronger driver of subtype bias to influenza viral strains. We found that covalent coupling of heterologous hemagglutinin (HA) from different viral strains could largely eliminate subtype bias in an animal model and in a human tonsil organoid system. We proposed that coupling of heterologous antigens improves antibody responses across influenza strains by broadening T cell help, and we found that using this approach substantially improved the antibody response to avian influenza HA.