tetano
Editor, Senior Moderator
Sci Transl Med
. 2022 Mar 8;eabn6150.
doi: 10.1126/scitranslmed.abn6150. Online ahead of print.
Characterization of immune responses in fully vaccinated individuals following breakthrough infection with the SARS-CoV-2 delta variant
Ai-Ris Y Collier[SUP] 1 2 3 [/SUP], Catherine M Brown[SUP] 4 [/SUP], Katherine A McMahan[SUP] 1 [/SUP], Jingyou Yu[SUP] 1 [/SUP], Jinyan Liu[SUP] 1 [/SUP], Catherine Jacob-Dolan[SUP] 1 2 [/SUP], Abishek Chandrashekar[SUP] 1 [/SUP], Dylan Tierney[SUP] 4 [/SUP], Jessica L Ansel[SUP] 1 [/SUP], Marjorie Rowe[SUP] 1 [/SUP], Daniel Sellers[SUP] 1 [/SUP], Kunza Ahmad[SUP] 1 [/SUP], Ricardo Aguayo[SUP] 1 3 [/SUP], Tochi Anioke[SUP] 1 [/SUP], Sarah Gardner[SUP] 1 [/SUP], Mazuba Siamatu[SUP] 1 [/SUP], Lorraine Bermudez Rivera[SUP] 1 [/SUP], Michele R Hacker[SUP] 2 3 [/SUP], Lawrence C Madoff[SUP] 4 [/SUP], Dan H Barouch[SUP] 1 2 5 [/SUP]
Affiliations
Abstract
Breakthrough infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have been reported frequently in vaccinated individuals with waning immunity. In particular, a cluster of over 1,000 infections with the SARS-CoV-2 delta variant was identified in a predominantly fully vaccinated population in Provincetown, Massachusetts in July 2021. In this study, vaccinated individuals who tested positive for SARS-CoV-2 (n=16) demonstrated substantially higher serum antibody responses than vaccinated individuals who tested negative for SARS-CoV-2 (n=23), including 32-fold higher binding antibody titers and 31-fold higher neutralizing antibody titers against the SARS-CoV-2 delta variant. Vaccinated individuals who tested positive also showed higher mucosal antibody responses in nasal secretions and higher Spike protein-specific CD8[SUP]+[/SUP] T cell responses in peripheral blood than did vaccinated individuals who tested negative. These data demonstrate that fully vaccinated individuals developed robust anamnestic antibody and T cell responses following infection with the SARS-CoV-2 delta variant. Moreover, these findings suggest that population immunity will likely increase over time by a combination of widespread vaccination and breakthrough infections.
. 2022 Mar 8;eabn6150.
doi: 10.1126/scitranslmed.abn6150. Online ahead of print.
Characterization of immune responses in fully vaccinated individuals following breakthrough infection with the SARS-CoV-2 delta variant
Ai-Ris Y Collier[SUP] 1 2 3 [/SUP], Catherine M Brown[SUP] 4 [/SUP], Katherine A McMahan[SUP] 1 [/SUP], Jingyou Yu[SUP] 1 [/SUP], Jinyan Liu[SUP] 1 [/SUP], Catherine Jacob-Dolan[SUP] 1 2 [/SUP], Abishek Chandrashekar[SUP] 1 [/SUP], Dylan Tierney[SUP] 4 [/SUP], Jessica L Ansel[SUP] 1 [/SUP], Marjorie Rowe[SUP] 1 [/SUP], Daniel Sellers[SUP] 1 [/SUP], Kunza Ahmad[SUP] 1 [/SUP], Ricardo Aguayo[SUP] 1 3 [/SUP], Tochi Anioke[SUP] 1 [/SUP], Sarah Gardner[SUP] 1 [/SUP], Mazuba Siamatu[SUP] 1 [/SUP], Lorraine Bermudez Rivera[SUP] 1 [/SUP], Michele R Hacker[SUP] 2 3 [/SUP], Lawrence C Madoff[SUP] 4 [/SUP], Dan H Barouch[SUP] 1 2 5 [/SUP]
Affiliations
- PMID: 35258323
- DOI: 10.1126/scitranslmed.abn6150
Abstract
Breakthrough infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have been reported frequently in vaccinated individuals with waning immunity. In particular, a cluster of over 1,000 infections with the SARS-CoV-2 delta variant was identified in a predominantly fully vaccinated population in Provincetown, Massachusetts in July 2021. In this study, vaccinated individuals who tested positive for SARS-CoV-2 (n=16) demonstrated substantially higher serum antibody responses than vaccinated individuals who tested negative for SARS-CoV-2 (n=23), including 32-fold higher binding antibody titers and 31-fold higher neutralizing antibody titers against the SARS-CoV-2 delta variant. Vaccinated individuals who tested positive also showed higher mucosal antibody responses in nasal secretions and higher Spike protein-specific CD8[SUP]+[/SUP] T cell responses in peripheral blood than did vaccinated individuals who tested negative. These data demonstrate that fully vaccinated individuals developed robust anamnestic antibody and T cell responses following infection with the SARS-CoV-2 delta variant. Moreover, these findings suggest that population immunity will likely increase over time by a combination of widespread vaccination and breakthrough infections.