tetano
Editor, Senior Moderator
Sci Transl Med
. 2022 Nov 16;14(671):eabo5795.
doi: 10.1126/scitranslmed.abo5795. Epub 2022 Nov 16.
A persistent neutrophil-associated immune signature characterizes post-COVID-19 pulmonary sequelae
Peter M George[SUP] 1 2 [/SUP], Anna Reed[SUP] 1 2 [/SUP], Sujal R Desai[SUP] 1 2 [/SUP], Anand Devaraj[SUP] 1 2 [/SUP], Tasnim Shahridan Faiez[SUP] 3 [/SUP], Sarah Laverty[SUP] 4 [/SUP], Amama Kanwal[SUP] 5 [/SUP], Camille Esneau[SUP] 5 [/SUP], Michael K C Liu[SUP] 4 [/SUP], Faisal Kamal[SUP] 6 [/SUP], William D-C Man[SUP] 1 2 7 [/SUP], Sundeep Kaul[SUP] 1 [/SUP], Suveer Singh[SUP] 1 [/SUP], Georgia Lamb[SUP] 1 [/SUP], Fatima K Faizi[SUP] 3 [/SUP], Michael Schuliga[SUP] 5 [/SUP], Jane Read[SUP] 5 [/SUP], Thomas Burgoyne[SUP] 1 8 [/SUP], Andreia L Pinto[SUP] 1 [/SUP], Jake Micallef[SUP] 9 [/SUP], Emilie Bauwens[SUP] 9 [/SUP], Julie Candiracci[SUP] 9 [/SUP], Mhammed Bougoussa[SUP] 9 [/SUP], Marielle Herzog[SUP] 9 [/SUP], Lavanya Raman[SUP] 2 [/SUP], Blerina Ahmetaj-Shala[SUP] 2 [/SUP], Stuart Turville[SUP] 10 [/SUP], Anupriya Aggarwal[SUP] 10 [/SUP], Hugo A Farne[SUP] 2 10 11 [/SUP], Alessia Dalla Pria[SUP] 4 12 [/SUP], Andrew D Aswani[SUP] 13 14 [/SUP], Francesca Patella[SUP] 15 [/SUP], Weronika E Borek[SUP] 15 [/SUP], Jane A Mitchell[SUP] 2 [/SUP], Nathan W Bartlett[SUP] 5 [/SUP], Arran Dokal[SUP] 15 [/SUP], Xiao-Ning Xu[SUP] 4 [/SUP], Peter Kelleher[SUP] 1 12 16 17 [/SUP], Anand Shah[SUP] 1 18 [/SUP], Aran Singanayagam[SUP] 3 [/SUP]
Affiliations
Abstract
Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through unknown mechanisms. We studied individuals with severe coronavirus disease 2019 (COVID-19) after recovery from acute illness. Individuals with evidence of interstitial lung changes at 3 to 6 months after recovery had an up-regulated neutrophil-associated immune signature including increased chemokines, proteases, and markers of neutrophil extracellular traps that were detectable in the blood. Similar pathways were enriched in the upper airway with a concomitant increase in antiviral type I interferon signaling. Interaction analysis of the peripheral phosphoproteome identified enriched kinases critical for neutrophil inflammatory pathways. Evaluation of these individuals at 12 months after recovery indicated that a subset of the individuals had not yet achieved full normalization of radiological and functional changes. These data provide insight into mechanisms driving development of pulmonary sequelae during and after COVID-19 and provide a rational basis for development of targeted approaches to prevent long-term complications.
. 2022 Nov 16;14(671):eabo5795.
doi: 10.1126/scitranslmed.abo5795. Epub 2022 Nov 16.
A persistent neutrophil-associated immune signature characterizes post-COVID-19 pulmonary sequelae
Peter M George[SUP] 1 2 [/SUP], Anna Reed[SUP] 1 2 [/SUP], Sujal R Desai[SUP] 1 2 [/SUP], Anand Devaraj[SUP] 1 2 [/SUP], Tasnim Shahridan Faiez[SUP] 3 [/SUP], Sarah Laverty[SUP] 4 [/SUP], Amama Kanwal[SUP] 5 [/SUP], Camille Esneau[SUP] 5 [/SUP], Michael K C Liu[SUP] 4 [/SUP], Faisal Kamal[SUP] 6 [/SUP], William D-C Man[SUP] 1 2 7 [/SUP], Sundeep Kaul[SUP] 1 [/SUP], Suveer Singh[SUP] 1 [/SUP], Georgia Lamb[SUP] 1 [/SUP], Fatima K Faizi[SUP] 3 [/SUP], Michael Schuliga[SUP] 5 [/SUP], Jane Read[SUP] 5 [/SUP], Thomas Burgoyne[SUP] 1 8 [/SUP], Andreia L Pinto[SUP] 1 [/SUP], Jake Micallef[SUP] 9 [/SUP], Emilie Bauwens[SUP] 9 [/SUP], Julie Candiracci[SUP] 9 [/SUP], Mhammed Bougoussa[SUP] 9 [/SUP], Marielle Herzog[SUP] 9 [/SUP], Lavanya Raman[SUP] 2 [/SUP], Blerina Ahmetaj-Shala[SUP] 2 [/SUP], Stuart Turville[SUP] 10 [/SUP], Anupriya Aggarwal[SUP] 10 [/SUP], Hugo A Farne[SUP] 2 10 11 [/SUP], Alessia Dalla Pria[SUP] 4 12 [/SUP], Andrew D Aswani[SUP] 13 14 [/SUP], Francesca Patella[SUP] 15 [/SUP], Weronika E Borek[SUP] 15 [/SUP], Jane A Mitchell[SUP] 2 [/SUP], Nathan W Bartlett[SUP] 5 [/SUP], Arran Dokal[SUP] 15 [/SUP], Xiao-Ning Xu[SUP] 4 [/SUP], Peter Kelleher[SUP] 1 12 16 17 [/SUP], Anand Shah[SUP] 1 18 [/SUP], Aran Singanayagam[SUP] 3 [/SUP]
Affiliations
- PMID: 36383686
- DOI: 10.1126/scitranslmed.abo5795
Abstract
Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through unknown mechanisms. We studied individuals with severe coronavirus disease 2019 (COVID-19) after recovery from acute illness. Individuals with evidence of interstitial lung changes at 3 to 6 months after recovery had an up-regulated neutrophil-associated immune signature including increased chemokines, proteases, and markers of neutrophil extracellular traps that were detectable in the blood. Similar pathways were enriched in the upper airway with a concomitant increase in antiviral type I interferon signaling. Interaction analysis of the peripheral phosphoproteome identified enriched kinases critical for neutrophil inflammatory pathways. Evaluation of these individuals at 12 months after recovery indicated that a subset of the individuals had not yet achieved full normalization of radiological and functional changes. These data provide insight into mechanisms driving development of pulmonary sequelae during and after COVID-19 and provide a rational basis for development of targeted approaches to prevent long-term complications.