tetano
Editor, Senior Moderator
Sci Rep
. 2024 Oct 19;14(1):24595.
doi: 10.1038/s41598-024-76506-7. Study on sentinel hosts for surveillance of future COVID-19-like outbreaks
Yanjiao Li[SUP] #[/SUP][SUP] 1 2 [/SUP], Jingjing Hu[SUP] #[/SUP][SUP] 1 2 [/SUP], Jingjing Hou[SUP] #[/SUP][SUP] 3 [/SUP], Shuiping Lu[SUP] #[/SUP][SUP] 1 2 [/SUP], Jiasheng Xiong[SUP] 4 [/SUP], Yuxi Wang[SUP] 1 2 [/SUP], Zhong Sun[SUP] 5 [/SUP], Weijie Chen[SUP] 1 2 [/SUP], Yue Pan[SUP] 1 2 [/SUP], Karuppiah Thilakavathy[SUP] 5 [/SUP], Yi Feng[SUP] 6 [/SUP], Qingwu Jiang[SUP] 1 2 [/SUP], Weibing Wang[SUP] 7 8 [/SUP], Chenglong Xiong[SUP] 9 10 [/SUP]
Affiliations
The spread of SARS-CoV-2 to animals has the potential to evolve independently. In this study, we distinguished several sentinel animal species and genera for monitoring the re-emergence of COVID-19 or the new outbreak of COVID-19-like disease. We analyzed SARS-CoV-2 genomic data from human and nonhuman mammals in the taxonomic hierarchies of species, genus, family and order of their host. We find that SARS-CoV-2 carried by domestic dog (Canis lupus familiaris), domestic cat (Felis catus), mink (Neovison vison), and white-tailed deer (Odocoileus virginianus) cluster closely to human-origin viruses and show no differences in the majority of amino acids, but have the most positively selected sites and should be monitored to prevent the re-emergence of COVID-19 caused by novel variants of SARS-CoV-2. Viruses from the genera Panthera (especially lion (Panthera leo)), Manis and Rhinolophus differ significantly from human-origin viruses, and long-term surveillance should be undertaken to prevent the future COVID-19-like outbreaks. Investigation of the variation dynamics of sites 142, 501, 655, 681 and 950 within the S protein may be necessary to predict the novel animal SARS-CoV-2 variants.
Keywords: Amino acid polymorphism; Phylogenetic tree; Positively selected site; SARS-CoV-2; Sentinel host; Spike protein.
. 2024 Oct 19;14(1):24595.
doi: 10.1038/s41598-024-76506-7. Study on sentinel hosts for surveillance of future COVID-19-like outbreaks
Yanjiao Li[SUP] #[/SUP][SUP] 1 2 [/SUP], Jingjing Hu[SUP] #[/SUP][SUP] 1 2 [/SUP], Jingjing Hou[SUP] #[/SUP][SUP] 3 [/SUP], Shuiping Lu[SUP] #[/SUP][SUP] 1 2 [/SUP], Jiasheng Xiong[SUP] 4 [/SUP], Yuxi Wang[SUP] 1 2 [/SUP], Zhong Sun[SUP] 5 [/SUP], Weijie Chen[SUP] 1 2 [/SUP], Yue Pan[SUP] 1 2 [/SUP], Karuppiah Thilakavathy[SUP] 5 [/SUP], Yi Feng[SUP] 6 [/SUP], Qingwu Jiang[SUP] 1 2 [/SUP], Weibing Wang[SUP] 7 8 [/SUP], Chenglong Xiong[SUP] 9 10 [/SUP]
Affiliations
- PMID: 39427096
- PMCID: PMC11490639
- DOI: 10.1038/s41598-024-76506-7
The spread of SARS-CoV-2 to animals has the potential to evolve independently. In this study, we distinguished several sentinel animal species and genera for monitoring the re-emergence of COVID-19 or the new outbreak of COVID-19-like disease. We analyzed SARS-CoV-2 genomic data from human and nonhuman mammals in the taxonomic hierarchies of species, genus, family and order of their host. We find that SARS-CoV-2 carried by domestic dog (Canis lupus familiaris), domestic cat (Felis catus), mink (Neovison vison), and white-tailed deer (Odocoileus virginianus) cluster closely to human-origin viruses and show no differences in the majority of amino acids, but have the most positively selected sites and should be monitored to prevent the re-emergence of COVID-19 caused by novel variants of SARS-CoV-2. Viruses from the genera Panthera (especially lion (Panthera leo)), Manis and Rhinolophus differ significantly from human-origin viruses, and long-term surveillance should be undertaken to prevent the future COVID-19-like outbreaks. Investigation of the variation dynamics of sites 142, 501, 655, 681 and 950 within the S protein may be necessary to predict the novel animal SARS-CoV-2 variants.
Keywords: Amino acid polymorphism; Phylogenetic tree; Positively selected site; SARS-CoV-2; Sentinel host; Spike protein.