tetano
Editor, Senior Moderator
Sci Rep
. 2022 Oct 20;12(1):17584.
doi: 10.1038/s41598-022-21177-5.
Remnant cholesterol levels are associated with severity and death in COVID-19 patients
Bibiana Fabre[SUP] 1 2 [/SUP], Nahuel Fernandez Machulsky[SUP] 1 2 [/SUP], Carolina Olano[SUP] 1 2 [/SUP], Darío Jacobsen[SUP] 1 [/SUP], María Eugenia Gómez[SUP] 1 [/SUP], Beatriz Perazzi[SUP] 1 2 [/SUP], Valeria Zago[SUP] 1 2 3 [/SUP], Damián Zopatti[SUP] 4 [/SUP], Andrés Ferrero[SUP] 5 [/SUP], Laura Schreier[SUP] 1 2 [/SUP], Gabriela Berg[SUP] 6 7 8 [/SUP]
Affiliations
Abstract
Coronavirus disease-19 (COVID-19) patients with severe complications present comorbidities like cardiovascular-disease, hypertension and type-2 diabetes mellitus (DM), sharing metabolic alterations like insulin resistance (IR) and dyslipidemia. Our objective was to evaluate the association among different components of the lipid-lipoprotein profile, such as remnant lipoprotein (RLP)-cholesterol, in patients with COVID-19, and to analyze their associations with the severity of the disease and death. We studied 193 patients (68 (29-96) years; 49.7% male) hospitalized for COVID-19 and 200 controls (46 (18-79) years; 52.5% male). Lipoprotein profile, glucose and procalcitonin were assessed. Patients presented higher glucose, TG, TG/HDL-cholesterol and RLP-cholesterol levels, but lower total, LDL, HDL and no-HDL-cholesterol levels (p < 0.001). When a binary logistic regression was performed, age, non-HDL-cholesterol, and RLP-cholesterol were associated with death (p = 0.005). As the COVID-19 condition worsened, according to procalcitonin tertiles, a decrease in all the cholesterol fractions (p < 0.03) was observed with no differences in TG, while levels of RLP-cholesterol and TG/HDL-cholesterol increased (p < 0.001). Lower levels of all the cholesterol fractions were related with the presence and severity of COVID-19, except for RLP-cholesterol levels and TG/HDL-cholesterol index. These alterations indicate a lipid metabolic disorder, characteristic of IR states in COVID-19 patients. RLP-cholesterol levels predicted severity and death in these patients.
. 2022 Oct 20;12(1):17584.
doi: 10.1038/s41598-022-21177-5.
Remnant cholesterol levels are associated with severity and death in COVID-19 patients
Bibiana Fabre[SUP] 1 2 [/SUP], Nahuel Fernandez Machulsky[SUP] 1 2 [/SUP], Carolina Olano[SUP] 1 2 [/SUP], Darío Jacobsen[SUP] 1 [/SUP], María Eugenia Gómez[SUP] 1 [/SUP], Beatriz Perazzi[SUP] 1 2 [/SUP], Valeria Zago[SUP] 1 2 3 [/SUP], Damián Zopatti[SUP] 4 [/SUP], Andrés Ferrero[SUP] 5 [/SUP], Laura Schreier[SUP] 1 2 [/SUP], Gabriela Berg[SUP] 6 7 8 [/SUP]
Affiliations
- PMID: 36266451
- DOI: 10.1038/s41598-022-21177-5
Abstract
Coronavirus disease-19 (COVID-19) patients with severe complications present comorbidities like cardiovascular-disease, hypertension and type-2 diabetes mellitus (DM), sharing metabolic alterations like insulin resistance (IR) and dyslipidemia. Our objective was to evaluate the association among different components of the lipid-lipoprotein profile, such as remnant lipoprotein (RLP)-cholesterol, in patients with COVID-19, and to analyze their associations with the severity of the disease and death. We studied 193 patients (68 (29-96) years; 49.7% male) hospitalized for COVID-19 and 200 controls (46 (18-79) years; 52.5% male). Lipoprotein profile, glucose and procalcitonin were assessed. Patients presented higher glucose, TG, TG/HDL-cholesterol and RLP-cholesterol levels, but lower total, LDL, HDL and no-HDL-cholesterol levels (p < 0.001). When a binary logistic regression was performed, age, non-HDL-cholesterol, and RLP-cholesterol were associated with death (p = 0.005). As the COVID-19 condition worsened, according to procalcitonin tertiles, a decrease in all the cholesterol fractions (p < 0.03) was observed with no differences in TG, while levels of RLP-cholesterol and TG/HDL-cholesterol increased (p < 0.001). Lower levels of all the cholesterol fractions were related with the presence and severity of COVID-19, except for RLP-cholesterol levels and TG/HDL-cholesterol index. These alterations indicate a lipid metabolic disorder, characteristic of IR states in COVID-19 patients. RLP-cholesterol levels predicted severity and death in these patients.