tetano
Editor, Senior Moderator
Sci Rep
. 2022 Dec 14;12(1):21582.
doi: 10.1038/s41598-022-25598-0.
Population-based sero-epidemiological investigation of the dynamics of SARS-CoV-2 infections in the Greater Accra Region of Ghana
Benedicta Ayiedu Mensah[SUP] #[/SUP][SUP] 1 [/SUP], Ignatius Cheng Ndong[SUP] #[/SUP][SUP] 2 3 [/SUP], Peter Kojo Quashie[SUP] 4 [/SUP], Emilande Guichet[SUP] 5 [/SUP], Benjamin Abuaku[SUP] 2 [/SUP], Yaw Effah-Baafi[SUP] 2 [/SUP], Kesego Tapela[SUP] 4 [/SUP], Kwame Asiedu[SUP] 4 [/SUP], Sekyibea Nana Ama Appiedu-Addo[SUP] 4 [/SUP], Louisa Baaba Obbeng[SUP] 4 [/SUP], Jones Amo Amponsah[SUP] 2 [/SUP], Kwadwo Asamoah Kusi[SUP] 2 [/SUP], Michael Ofori[SUP] 2 [/SUP], Ahidjo Ayouba[SUP] 5 [/SUP], David Courtin[SUP] 6 [/SUP], Rachida Tahar[SUP] 6 [/SUP], Eric Delaporte[SUP] 5 [/SUP], Gordon Awandare[SUP] 4 [/SUP], Nicaise Tuikue Ndam[SUP] 7 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) pandemic devastated countries worldwide, and resulted in a global shutdown. Not all infections are symptomatic and hence the extent of SARS-CoV-2 infection in the community is unknown. The paper presents the dynamics of the SARS-CoV-2 epidemic in the Greater Accra Metropolis, describing the evolution of seroprevalence through time and by age group. Three repeated independent population-based surveys at 6-week intervals were conducted in from November 2020 to July 2021. The global and by age-groups weighted seroprevalences were estimated and the risk factors for SARS-CoV-2 antibody seropositivity were assessed using logistic regression. The overall age-standardized SARS-CoV-2 antibody seroprevalence for both spike and nucleocapsid increased from 13.8% (95% CI 11.9, 16.1) in November 2020 to 39.6% (95% CI 34.8, 44.6) in July 2021. After controlling for gender, marital status, education level, and occupation, the older age group over 40 years had a higher odds of seropositivity than the younger age group (OR 3.0 [95% CI 1.1-8.5]) in the final survey. Pupils or students had 3.3-fold increased odds of seropositivity (OR 3.2 [95% CI 1.1-8.5]) compared to the unemployed. This study reinforces that, SARS-CoV-2 infections have been significantly higher than reported.
. 2022 Dec 14;12(1):21582.
doi: 10.1038/s41598-022-25598-0.
Population-based sero-epidemiological investigation of the dynamics of SARS-CoV-2 infections in the Greater Accra Region of Ghana
Benedicta Ayiedu Mensah[SUP] #[/SUP][SUP] 1 [/SUP], Ignatius Cheng Ndong[SUP] #[/SUP][SUP] 2 3 [/SUP], Peter Kojo Quashie[SUP] 4 [/SUP], Emilande Guichet[SUP] 5 [/SUP], Benjamin Abuaku[SUP] 2 [/SUP], Yaw Effah-Baafi[SUP] 2 [/SUP], Kesego Tapela[SUP] 4 [/SUP], Kwame Asiedu[SUP] 4 [/SUP], Sekyibea Nana Ama Appiedu-Addo[SUP] 4 [/SUP], Louisa Baaba Obbeng[SUP] 4 [/SUP], Jones Amo Amponsah[SUP] 2 [/SUP], Kwadwo Asamoah Kusi[SUP] 2 [/SUP], Michael Ofori[SUP] 2 [/SUP], Ahidjo Ayouba[SUP] 5 [/SUP], David Courtin[SUP] 6 [/SUP], Rachida Tahar[SUP] 6 [/SUP], Eric Delaporte[SUP] 5 [/SUP], Gordon Awandare[SUP] 4 [/SUP], Nicaise Tuikue Ndam[SUP] 7 [/SUP]
Affiliations
- PMID: 36517505
- DOI: 10.1038/s41598-022-25598-0
Abstract
The coronavirus disease 2019 (COVID-19) pandemic devastated countries worldwide, and resulted in a global shutdown. Not all infections are symptomatic and hence the extent of SARS-CoV-2 infection in the community is unknown. The paper presents the dynamics of the SARS-CoV-2 epidemic in the Greater Accra Metropolis, describing the evolution of seroprevalence through time and by age group. Three repeated independent population-based surveys at 6-week intervals were conducted in from November 2020 to July 2021. The global and by age-groups weighted seroprevalences were estimated and the risk factors for SARS-CoV-2 antibody seropositivity were assessed using logistic regression. The overall age-standardized SARS-CoV-2 antibody seroprevalence for both spike and nucleocapsid increased from 13.8% (95% CI 11.9, 16.1) in November 2020 to 39.6% (95% CI 34.8, 44.6) in July 2021. After controlling for gender, marital status, education level, and occupation, the older age group over 40 years had a higher odds of seropositivity than the younger age group (OR 3.0 [95% CI 1.1-8.5]) in the final survey. Pupils or students had 3.3-fold increased odds of seropositivity (OR 3.2 [95% CI 1.1-8.5]) compared to the unemployed. This study reinforces that, SARS-CoV-2 infections have been significantly higher than reported.