tetano
Editor, Senior Moderator
Sci Rep
. 2025 May 17;15(1):17211.
doi: 10.1038/s41598-025-97289-5. Natural, vaccine-induced immunity and the probability of experiencing SARS-CoV-2 infection in a household cohort in Rio de Janeiro
Michele F B da Silva[SUP] 1 [/SUP], Lusiele Guaraldo[SUP] 1 [/SUP], Leonardo Soares Bastos[SUP] 2 [/SUP], Heloisa F P Santos[SUP] 1 [/SUP], Otávio M Espíndola[SUP] 1 [/SUP], Paola Cristina Resende[SUP] 3 [/SUP], Stephanie L S Penetra[SUP] 1 [/SUP], Anielle Pina-Costa[SUP] 1 [/SUP], Isabella C V de Moraes[SUP] 1 [/SUP], Guilherme A Calvet[SUP] 1 [/SUP], Trevon L Fuller[SUP] 1 4 [/SUP], Marilda M Siqueira[SUP] 3 [/SUP], Marilia Sá Carvalho[SUP] 2 [/SUP], Patricia Brasil[SUP] 5 [/SUP]
Affiliations
The impact of COVID-19 vaccines on real-world transmission remains poorly understood and represents a key public health challenge. This study aimed to investigate natural, vaccine-induced immunity and the probability of experiencing SARS-CoV-2 infection in a cohort of families living in Rio de Janeiro. The participants were categorized into immune groups based on recent infection (within the past 9 months) and vaccination status, considering the type of vaccine received, the number of doses, and the strength of their immune response over time. We estimated the transmission probability within clusters using a multivariate model. From May 2020 to June 2023, we enrolled 669 individuals from 182 households; 272 clusters and 288 index cases were identified. Household transmission occurred in 124 (45.6%) clusters. During the pre-VoC period we did not find any factors associated with transmission. In the Gamma/Delta period, previous infections reduced the probability of transmission (OR = 0.088; 95%CI 0.023-0.341), while in the Omicron period, having a healthcare worker in the household (OR = 0.486; 95%CI 0.256-0.921) and hybrid immunity (OR = 0.095; 95%CI 0.010-0.924) decreased the probability of transmission. Our findings provide strong support for the protective effect of regular vaccination against household transmission in a cohort of families exposed to successive SARS-CoV-2 variants.
Keywords: COVID-19; COVID-19 vaccine; Cohort study; Household transmission; Immunity; SARS-CoV-2 variants.
. 2025 May 17;15(1):17211.
doi: 10.1038/s41598-025-97289-5. Natural, vaccine-induced immunity and the probability of experiencing SARS-CoV-2 infection in a household cohort in Rio de Janeiro
Michele F B da Silva[SUP] 1 [/SUP], Lusiele Guaraldo[SUP] 1 [/SUP], Leonardo Soares Bastos[SUP] 2 [/SUP], Heloisa F P Santos[SUP] 1 [/SUP], Otávio M Espíndola[SUP] 1 [/SUP], Paola Cristina Resende[SUP] 3 [/SUP], Stephanie L S Penetra[SUP] 1 [/SUP], Anielle Pina-Costa[SUP] 1 [/SUP], Isabella C V de Moraes[SUP] 1 [/SUP], Guilherme A Calvet[SUP] 1 [/SUP], Trevon L Fuller[SUP] 1 4 [/SUP], Marilda M Siqueira[SUP] 3 [/SUP], Marilia Sá Carvalho[SUP] 2 [/SUP], Patricia Brasil[SUP] 5 [/SUP]
Affiliations
- PMID: 40382467
- PMCID: PMC12085559
- DOI: 10.1038/s41598-025-97289-5
The impact of COVID-19 vaccines on real-world transmission remains poorly understood and represents a key public health challenge. This study aimed to investigate natural, vaccine-induced immunity and the probability of experiencing SARS-CoV-2 infection in a cohort of families living in Rio de Janeiro. The participants were categorized into immune groups based on recent infection (within the past 9 months) and vaccination status, considering the type of vaccine received, the number of doses, and the strength of their immune response over time. We estimated the transmission probability within clusters using a multivariate model. From May 2020 to June 2023, we enrolled 669 individuals from 182 households; 272 clusters and 288 index cases were identified. Household transmission occurred in 124 (45.6%) clusters. During the pre-VoC period we did not find any factors associated with transmission. In the Gamma/Delta period, previous infections reduced the probability of transmission (OR = 0.088; 95%CI 0.023-0.341), while in the Omicron period, having a healthcare worker in the household (OR = 0.486; 95%CI 0.256-0.921) and hybrid immunity (OR = 0.095; 95%CI 0.010-0.924) decreased the probability of transmission. Our findings provide strong support for the protective effect of regular vaccination against household transmission in a cohort of families exposed to successive SARS-CoV-2 variants.
Keywords: COVID-19; COVID-19 vaccine; Cohort study; Household transmission; Immunity; SARS-CoV-2 variants.