tetano
Editor, Senior Moderator
Sci Rep
. 2024 Oct 17;14(1):24400.
doi: 10.1038/s41598-024-73940-5. Nationwide Cohort observational study on the safety and efficacy of COVID-19 vaccination in patients with Moyamoya disease
Hyoung Soo Byoun[SUP] 1 [/SUP], Si Un Lee[SUP] #[/SUP][SUP] 2 [/SUP], Yu Deok Won[SUP] #[/SUP][SUP] 3 [/SUP], Tae Won Choi[SUP] 4 [/SUP], Sang Hyo Lee[SUP] 4 [/SUP], Young-Deok Kim[SUP] 4 [/SUP], Seung Pil Ban[SUP] 4 [/SUP], Jae Seung Bang[SUP] 4 [/SUP], O-Ki Kwon[SUP] 4 [/SUP], Chang Wan Oh[SUP] 4 [/SUP]
Affiliations
The safety and efficacy of coronavirus disease 2019 (COVID-19) vaccination in patients diagnosed with Moyamoya disease (MMD) have not been established. Using National Health Insurance Service data, this study analyzed the occurrence of stroke-related events and mortality following COVID-19 vaccination among patients diagnosed with MMD from 2008 to 2020. Among 10,297 MMD patients, 296 (2.9%) experienced events and 175 (1.7%) died in 2021. Significant risk factors for events included ages 50-59 (Odds Ratio [OR] 3.29; P = 0.022) and 60 or above (OR 5.20; P = 0.001) (reference group: age in 20s), low BMI (OR 2.00; P = 0.011), previous stroke (OR 1.96; P < 0.001), and COVID-19 infection (OR 2.28; P = 0.034). Female (OR 0.64 [95% CI 0.50-0.82]; p = 0.011), revascularization surgery (RS) (OR 0.38 [95% CI 0.21-0.70]; p < 0.001), and vaccination (OR 0.17 [95% CI 0.13-0.22]; p < 0.001) were associated with reduced odds of stroke-related events. For mortality, significant risks were age over 60 (OR 7.09; P = 0.008), low BMI (OR 3.87; P = 0.001), and prior stroke (OR 1.74; p = 0.004), while being female, RS (OR 0.41; P = 0.022), and vaccination (OR 0.12; P < 0.001) were associated with a lower frequency of mortality. mRNA vaccines were associated with a significantly lower incidence of events, mortality, and COVID-19 infections compared to vector vaccines. COVID-19 vaccination is linked to reduced stroke-related events and mortality in MMD patients, with mRNA vaccines showing a significantly lower incidence compared to vector vaccines. COVID-19 infection raises the risk of events, underscoring the benefit of vaccination.
Keywords: Coronavirus disease; Moyamoya disease; Stroke; Vaccination.
. 2024 Oct 17;14(1):24400.
doi: 10.1038/s41598-024-73940-5. Nationwide Cohort observational study on the safety and efficacy of COVID-19 vaccination in patients with Moyamoya disease
Hyoung Soo Byoun[SUP] 1 [/SUP], Si Un Lee[SUP] #[/SUP][SUP] 2 [/SUP], Yu Deok Won[SUP] #[/SUP][SUP] 3 [/SUP], Tae Won Choi[SUP] 4 [/SUP], Sang Hyo Lee[SUP] 4 [/SUP], Young-Deok Kim[SUP] 4 [/SUP], Seung Pil Ban[SUP] 4 [/SUP], Jae Seung Bang[SUP] 4 [/SUP], O-Ki Kwon[SUP] 4 [/SUP], Chang Wan Oh[SUP] 4 [/SUP]
Affiliations
- PMID: 39420039
- PMCID: PMC11487014
- DOI: 10.1038/s41598-024-73940-5
The safety and efficacy of coronavirus disease 2019 (COVID-19) vaccination in patients diagnosed with Moyamoya disease (MMD) have not been established. Using National Health Insurance Service data, this study analyzed the occurrence of stroke-related events and mortality following COVID-19 vaccination among patients diagnosed with MMD from 2008 to 2020. Among 10,297 MMD patients, 296 (2.9%) experienced events and 175 (1.7%) died in 2021. Significant risk factors for events included ages 50-59 (Odds Ratio [OR] 3.29; P = 0.022) and 60 or above (OR 5.20; P = 0.001) (reference group: age in 20s), low BMI (OR 2.00; P = 0.011), previous stroke (OR 1.96; P < 0.001), and COVID-19 infection (OR 2.28; P = 0.034). Female (OR 0.64 [95% CI 0.50-0.82]; p = 0.011), revascularization surgery (RS) (OR 0.38 [95% CI 0.21-0.70]; p < 0.001), and vaccination (OR 0.17 [95% CI 0.13-0.22]; p < 0.001) were associated with reduced odds of stroke-related events. For mortality, significant risks were age over 60 (OR 7.09; P = 0.008), low BMI (OR 3.87; P = 0.001), and prior stroke (OR 1.74; p = 0.004), while being female, RS (OR 0.41; P = 0.022), and vaccination (OR 0.12; P < 0.001) were associated with a lower frequency of mortality. mRNA vaccines were associated with a significantly lower incidence of events, mortality, and COVID-19 infections compared to vector vaccines. COVID-19 vaccination is linked to reduced stroke-related events and mortality in MMD patients, with mRNA vaccines showing a significantly lower incidence compared to vector vaccines. COVID-19 infection raises the risk of events, underscoring the benefit of vaccination.
Keywords: Coronavirus disease; Moyamoya disease; Stroke; Vaccination.