tetano
Editor, Senior Moderator
Sci Rep
. 2026 Aug 8;16(1):24551.
doi: 10.1038/s41598-026-62965-7.
Inter-hospital ICU-to-ICU transfer of critically ill COVID-19 patients is not associated with increased mortality: a systematic review with exploratory meta-analysis
Jonas Brock[SUP] 1 2 3 [/SUP], Harald Lux[SUP] 4 5 6 [/SUP], Michael Bauer[SUP] 4 [/SUP], Petra Dickmann[SUP] 4 5 6 [/SUP]
Affiliations
During the COVID-19 pandemic, inter-hospital transfer of critically ill patients between intensive care units was widely used to manage capacity shortages. While several individual studies have compared outcomes of transferred and non-transferred patients, no systematic synthesis of this evidence exists. This systematic review aims to determine whether inter-hospital ICU-to-ICU transfer of adult COVID-19 patients is associated with increased mortality or other adverse clinical outcomes. We systematically searched PubMed, Web of Science, and Scopus for observational studies comparing clinical outcomes of adult COVID-19 patients who underwent inter-hospital ICU-to-ICU transfer with non-transferred ICU patients. Two reviewers screened, selected, and extracted data independently and in duplicate. Risk of bias was assessed using the Newcastle-Ottawa Scale and ROBINS-I, and certainty of evidence using GRADE. Exploratory random-effects meta-analyses were performed separately for each effect measure, with Hartung-Knapp and crude-effect sensitivity analyses. Nine observational studies from seven countries were included (approximately 6,100 transferred and 29,200 non-transferred ICU patients). None of the adjusted effect estimates showed a statistically significant mortality disadvantage for transferred patients. Pooled adjusted subgroup estimates were an odds ratio of 1.29 (95% CI 0.84 to 1.98; k = 3) and a hazard ratio of 0.71 (95% CI 0.34 to 1.46; k = 2). Length of stay was longer in transferred patients in most studies. The available observational evidence did not show a clear increase in mortality among transferred compared with non-transferred COVID-19 ICU patients. These findings support the use of inter-hospital transfer as a safe strategy for managing ICU surge capacity. PROSPERO CRD420261356915.
Keywords: COVID-19; Critically ill; Intensive care unit; Inter-hospital transfer; Length of stay; Mechanical ventilation; Meta-analysis; Mortality; Patient transfer; Systematic review.
. 2026 Aug 8;16(1):24551.
doi: 10.1038/s41598-026-62965-7.
Inter-hospital ICU-to-ICU transfer of critically ill COVID-19 patients is not associated with increased mortality: a systematic review with exploratory meta-analysis
Jonas Brock[SUP] 1 2 3 [/SUP], Harald Lux[SUP] 4 5 6 [/SUP], Michael Bauer[SUP] 4 [/SUP], Petra Dickmann[SUP] 4 5 6 [/SUP]
Affiliations
- PMID: 42570952
- PMCID: PMC13452817
- DOI: 10.1038/s41598-026-62965-7
During the COVID-19 pandemic, inter-hospital transfer of critically ill patients between intensive care units was widely used to manage capacity shortages. While several individual studies have compared outcomes of transferred and non-transferred patients, no systematic synthesis of this evidence exists. This systematic review aims to determine whether inter-hospital ICU-to-ICU transfer of adult COVID-19 patients is associated with increased mortality or other adverse clinical outcomes. We systematically searched PubMed, Web of Science, and Scopus for observational studies comparing clinical outcomes of adult COVID-19 patients who underwent inter-hospital ICU-to-ICU transfer with non-transferred ICU patients. Two reviewers screened, selected, and extracted data independently and in duplicate. Risk of bias was assessed using the Newcastle-Ottawa Scale and ROBINS-I, and certainty of evidence using GRADE. Exploratory random-effects meta-analyses were performed separately for each effect measure, with Hartung-Knapp and crude-effect sensitivity analyses. Nine observational studies from seven countries were included (approximately 6,100 transferred and 29,200 non-transferred ICU patients). None of the adjusted effect estimates showed a statistically significant mortality disadvantage for transferred patients. Pooled adjusted subgroup estimates were an odds ratio of 1.29 (95% CI 0.84 to 1.98; k = 3) and a hazard ratio of 0.71 (95% CI 0.34 to 1.46; k = 2). Length of stay was longer in transferred patients in most studies. The available observational evidence did not show a clear increase in mortality among transferred compared with non-transferred COVID-19 ICU patients. These findings support the use of inter-hospital transfer as a safe strategy for managing ICU surge capacity. PROSPERO CRD420261356915.
Keywords: COVID-19; Critically ill; Intensive care unit; Inter-hospital transfer; Length of stay; Mechanical ventilation; Meta-analysis; Mortality; Patient transfer; Systematic review.