tetano
Editor, Senior Moderator
Sci Rep
. 2024 Mar 2;14(1):5177.
doi: 10.1038/s41598-024-55697-z. Impact of COVID-19 versus other pneumonia on in-hospital mortality and functional decline among Japanese dialysis patients: a retrospective cohort study
Ken Ikenouchi[SUP] #[/SUP][SUP] 1 2 [/SUP], Daiei Takahashi[SUP] #[/SUP][SUP] 2 [/SUP], Shintaro Mandai[SUP] 3 [/SUP], Mizuki Watada[SUP] 2 [/SUP], Sayumi Koyama[SUP] 2 [/SUP], Motoki Hoshino[SUP] 2 [/SUP], Naohiro Takahashi[SUP] 2 [/SUP], Wakana Shoda[SUP] 2 [/SUP], Tamaki Kuyama[SUP] 2 [/SUP], Yutaro Mori[SUP] 1 [/SUP], Fumiaki Ando[SUP] 1 [/SUP], Koichiro Susa[SUP] 1 [/SUP], Takayasu Mori[SUP] 1 [/SUP], Soichiro Iimori[SUP] 1 [/SUP], Shotaro Naito[SUP] 1 [/SUP], Eisei Sohara[SUP] 1 [/SUP], Kiyohide Fushimi[SUP] 4 [/SUP], Shinichi Uchida[SUP] 5 [/SUP]
Affiliations
Coronavirus disease 2019 (COVID-19) affects both life and health. However, the differentiation from other types of pneumonia and effect of kidney disease remains uncertain. This retrospective observational study investigated the risk of in-hospital death and functional decline in ≥ 20% of Barthel Index scores after COVID-19 compared to other forms of pneumonia among Japanese adults, both with and without end-stage kidney disease (ESKD). The study enrolled 123,378 patients aged 18 years and older from a national inpatient administrative claims database in Japan that covers the first three waves of the COVID-19 pandemic in 2020. After a 1:1:1:1 propensity score matching into non-COVID-19/non-dialysis, COVID-19/non-dialysis, non-COVID-19/dialysis, and COVID-19/dialysis groups, 2136 adults were included in the analyses. The multivariable logistic regression analyses revealed greater odds ratios (ORs) of death [5.92 (95% CI 3.62-9.96)] and functional decline [1.93 (95% CI 1.26-2.99)] only in the COVID-19/dialysis group versus the non-COVID-19/non-dialysis group. The COVID-19/dialysis group had a higher risk of death directly due to pneumonia (OR 6.02, 95% CI 3.50-10.8) or death due to other diseases (OR 3.00, 95% CI 1.11-8.48; versus the non-COVID-19/non-dialysis group). COVID-19 displayed a greater impact on physical function than other types of pneumonia particularly in ESKD.
. 2024 Mar 2;14(1):5177.
doi: 10.1038/s41598-024-55697-z. Impact of COVID-19 versus other pneumonia on in-hospital mortality and functional decline among Japanese dialysis patients: a retrospective cohort study
Ken Ikenouchi[SUP] #[/SUP][SUP] 1 2 [/SUP], Daiei Takahashi[SUP] #[/SUP][SUP] 2 [/SUP], Shintaro Mandai[SUP] 3 [/SUP], Mizuki Watada[SUP] 2 [/SUP], Sayumi Koyama[SUP] 2 [/SUP], Motoki Hoshino[SUP] 2 [/SUP], Naohiro Takahashi[SUP] 2 [/SUP], Wakana Shoda[SUP] 2 [/SUP], Tamaki Kuyama[SUP] 2 [/SUP], Yutaro Mori[SUP] 1 [/SUP], Fumiaki Ando[SUP] 1 [/SUP], Koichiro Susa[SUP] 1 [/SUP], Takayasu Mori[SUP] 1 [/SUP], Soichiro Iimori[SUP] 1 [/SUP], Shotaro Naito[SUP] 1 [/SUP], Eisei Sohara[SUP] 1 [/SUP], Kiyohide Fushimi[SUP] 4 [/SUP], Shinichi Uchida[SUP] 5 [/SUP]
Affiliations
- PMID: 38431709
- DOI: 10.1038/s41598-024-55697-z
Coronavirus disease 2019 (COVID-19) affects both life and health. However, the differentiation from other types of pneumonia and effect of kidney disease remains uncertain. This retrospective observational study investigated the risk of in-hospital death and functional decline in ≥ 20% of Barthel Index scores after COVID-19 compared to other forms of pneumonia among Japanese adults, both with and without end-stage kidney disease (ESKD). The study enrolled 123,378 patients aged 18 years and older from a national inpatient administrative claims database in Japan that covers the first three waves of the COVID-19 pandemic in 2020. After a 1:1:1:1 propensity score matching into non-COVID-19/non-dialysis, COVID-19/non-dialysis, non-COVID-19/dialysis, and COVID-19/dialysis groups, 2136 adults were included in the analyses. The multivariable logistic regression analyses revealed greater odds ratios (ORs) of death [5.92 (95% CI 3.62-9.96)] and functional decline [1.93 (95% CI 1.26-2.99)] only in the COVID-19/dialysis group versus the non-COVID-19/non-dialysis group. The COVID-19/dialysis group had a higher risk of death directly due to pneumonia (OR 6.02, 95% CI 3.50-10.8) or death due to other diseases (OR 3.00, 95% CI 1.11-8.48; versus the non-COVID-19/non-dialysis group). COVID-19 displayed a greater impact on physical function than other types of pneumonia particularly in ESKD.