tetano
Editor, Senior Moderator
Sci Rep
. 2024 May 30;14(1):12443.
doi: 10.1038/s41598-024-63078-9. Disseminated intravascular coagulation is associated with poor prognosis in patients with COVID-19
Satoshi Gando[SUP] 1 2 [/SUP], Takayuki Akiyama[SUP] 3 4 [/SUP]
Affiliations
This study aimed to investigate the incidence and significance of disseminated intravascular coagulation (DIC) in coronavirus disease 2019 (COVID-19). A multicenter cohort study was conducted using large-scale COVID-19 registry data. The patients were classified into DIC and non-DIC groups based on the diagnosis on admission (day 1) and on any of the days 1, 4, 8, and 15. In total, 23,054 patients were divided into DIC (n = 264) and non-DIC (n = 22,790) groups on admission. Thereafter, 1654 patients were divided into 181 patients with DIC and 1473 non-DIC patients based on the DIC diagnosis on any of the days from 1 to 15. DIC incidence was 1.1% on admission, increasing to 10.9% by day 15. DIC diagnosis on admission had moderate predictive performance for developing multiple organ dysfunction syndrome (MODS) on day 4 and in-hospital death and was independently associated with MODS and in-hospital death. DIC diagnosis on any of the days from 1 to 15, especially days 8 and 15, was associated with lower survival probability than those without DIC and showed significant association with in-hospital death. In conclusion, despite its low incidence, DIC, particularly late-onset DIC, plays a significant role in the pathogenesis of poor prognosis in patients with COVID-19.
Keywords: Coronavirus disease 2019 (COVID-19); Disseminated intravascular coagulation (DIC); Incidence; Organ dysfunction; Prognosis.
. 2024 May 30;14(1):12443.
doi: 10.1038/s41598-024-63078-9. Disseminated intravascular coagulation is associated with poor prognosis in patients with COVID-19
Satoshi Gando[SUP] 1 2 [/SUP], Takayuki Akiyama[SUP] 3 4 [/SUP]
Affiliations
- PMID: 38816405
- DOI: 10.1038/s41598-024-63078-9
This study aimed to investigate the incidence and significance of disseminated intravascular coagulation (DIC) in coronavirus disease 2019 (COVID-19). A multicenter cohort study was conducted using large-scale COVID-19 registry data. The patients were classified into DIC and non-DIC groups based on the diagnosis on admission (day 1) and on any of the days 1, 4, 8, and 15. In total, 23,054 patients were divided into DIC (n = 264) and non-DIC (n = 22,790) groups on admission. Thereafter, 1654 patients were divided into 181 patients with DIC and 1473 non-DIC patients based on the DIC diagnosis on any of the days from 1 to 15. DIC incidence was 1.1% on admission, increasing to 10.9% by day 15. DIC diagnosis on admission had moderate predictive performance for developing multiple organ dysfunction syndrome (MODS) on day 4 and in-hospital death and was independently associated with MODS and in-hospital death. DIC diagnosis on any of the days from 1 to 15, especially days 8 and 15, was associated with lower survival probability than those without DIC and showed significant association with in-hospital death. In conclusion, despite its low incidence, DIC, particularly late-onset DIC, plays a significant role in the pathogenesis of poor prognosis in patients with COVID-19.
Keywords: Coronavirus disease 2019 (COVID-19); Disseminated intravascular coagulation (DIC); Incidence; Organ dysfunction; Prognosis.