tetano
Editor, Senior Moderator
Sci Rep
. 2024 May 20;14(1):11467.
doi: 10.1038/s41598-024-61922-6. Antibody longevity and waning following COVID-19 vaccination in a 1-year longitudinal cohort in Bangladesh
Md Ahsanul Haq[SUP] #[/SUP][SUP] 1 [/SUP], Anjan Kumar Roy[SUP] #[/SUP][SUP] 1 [/SUP], Razu Ahmed[SUP] 1 [/SUP], Rakib Ullah Kuddusi[SUP] 1 [/SUP], Monika Sinha[SUP] 1 [/SUP], Md Shamim Hossain[SUP] 1 [/SUP], Maya Vandenent[SUP] 2 [/SUP], Mohammad Zahirul Islam[SUP] 3 [/SUP], Rashid U Zaman[SUP] 4 [/SUP], Md Golam Kibria[SUP] 5 [/SUP], Abdur Razzaque[SUP] 1 [/SUP], Rubhana Raqib[SUP] 1 [/SUP], Protim Sarker[SUP] 6 [/SUP]
Affiliations
COVID-19 vaccines have been effective in preventing severe illness, hospitalization and death, however, the effectiveness diminishes with time. Here, we evaluated the longevity of antibodies generated by COIVD-19 vaccines and the risk of (re)infection in Bangladeshi population. Adults receiving two doses of AstraZeneca, Pfizer, Moderna or Sinopharm vaccines were enrolled at 2-4 weeks after second dosing and followed-up at 4-monthly interval for 1 year. Data on COVID-like symptoms, confirmed COVID-19 infection, co-morbidities, and receipt of booster dose were collected; blood was collected for measuring spike (S)- and nucleocapsid (N)-specific antibodies. S-specific antibody titers reduced by ~ 50% at 1st follow-up visit and continued to decline unless re-stimulated by booster vaccine dose or (re)infection. Individuals infected between follow-up visits showed significantly lower S-antibody titers at preceding visits compared to the uninfected individuals. Pre-enrolment infection between primary vaccination dosing exhibited 60% and 50% protection against reinfection at 5 and 9 months, respectively. mRNA vaccines provided highest odds of protection from (re)infection up to 5 months (Odds Ratio (OR) = 0.08), however, protection persisted for 9 months in AstraZeneca vaccine recipients (OR = 0.06). In conclusion, vaccine-mediated protection from (re)infection is partially linked to elevated levels of S-specific antibodies. AstraZeneca vaccine provided the longest protection.
. 2024 May 20;14(1):11467.
doi: 10.1038/s41598-024-61922-6. Antibody longevity and waning following COVID-19 vaccination in a 1-year longitudinal cohort in Bangladesh
Md Ahsanul Haq[SUP] #[/SUP][SUP] 1 [/SUP], Anjan Kumar Roy[SUP] #[/SUP][SUP] 1 [/SUP], Razu Ahmed[SUP] 1 [/SUP], Rakib Ullah Kuddusi[SUP] 1 [/SUP], Monika Sinha[SUP] 1 [/SUP], Md Shamim Hossain[SUP] 1 [/SUP], Maya Vandenent[SUP] 2 [/SUP], Mohammad Zahirul Islam[SUP] 3 [/SUP], Rashid U Zaman[SUP] 4 [/SUP], Md Golam Kibria[SUP] 5 [/SUP], Abdur Razzaque[SUP] 1 [/SUP], Rubhana Raqib[SUP] 1 [/SUP], Protim Sarker[SUP] 6 [/SUP]
Affiliations
- PMID: 38769324
- DOI: 10.1038/s41598-024-61922-6
COVID-19 vaccines have been effective in preventing severe illness, hospitalization and death, however, the effectiveness diminishes with time. Here, we evaluated the longevity of antibodies generated by COIVD-19 vaccines and the risk of (re)infection in Bangladeshi population. Adults receiving two doses of AstraZeneca, Pfizer, Moderna or Sinopharm vaccines were enrolled at 2-4 weeks after second dosing and followed-up at 4-monthly interval for 1 year. Data on COVID-like symptoms, confirmed COVID-19 infection, co-morbidities, and receipt of booster dose were collected; blood was collected for measuring spike (S)- and nucleocapsid (N)-specific antibodies. S-specific antibody titers reduced by ~ 50% at 1st follow-up visit and continued to decline unless re-stimulated by booster vaccine dose or (re)infection. Individuals infected between follow-up visits showed significantly lower S-antibody titers at preceding visits compared to the uninfected individuals. Pre-enrolment infection between primary vaccination dosing exhibited 60% and 50% protection against reinfection at 5 and 9 months, respectively. mRNA vaccines provided highest odds of protection from (re)infection up to 5 months (Odds Ratio (OR) = 0.08), however, protection persisted for 9 months in AstraZeneca vaccine recipients (OR = 0.06). In conclusion, vaccine-mediated protection from (re)infection is partially linked to elevated levels of S-specific antibodies. AstraZeneca vaccine provided the longest protection.