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SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation

Emily

Emily

Editor, Senior Moderator
https://immunology.sciencemag.org/content/6/58/eabg0833

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation


By Bingyu Yan, Tilo Freiwald, Daniel Chauss, Luopin Wang, Erin West, Carmen Mirabelli, Charles J Zhang, Eva-Maria Nichols, Nazish Malik, Richard Gregory, Marcus Bantscheff, Sonja Ghidelli-Disse, Martin Kolev, Tristan Frum, Jason R Spence, Jonathan Z. Sexton, Konstantinos D. Alysandratos, Darrell N. Kotton, Stefania Pittaluga, Jack Bibby, Nathalie Niyonzima, Matthew R Olson, Shahram Kordasti, Didier Portilla, Christiane E Wobus, Arian Laurence, Michail S Lionakis, Claudia Kemper, Behdad Afzali, Majid Kazemian

Science Immunology07 Apr 2021

SARS-CoV-2 induces JAK-STAT1?dependent complement C3 transcription and processing by a cell-intrinsic alternative pathway convertase.
 
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