Emily
Editor, Senior Moderator
https://journals.sagepub.com/doi/full/10.1177/1934578X21991723
Article first published online: April 3, 2021; Issue published: April 1, 2021
Accepted: January 08, 2021; Received: December 28, 2020
https://doi.org/10.1177/1934578X21991723
Pawan K. Agrawal[SUP]1[/SUP], Chandan Agrawal[SUP]1[/SUP], Gerald Blunden[SUP]2[/SUP]
[SUP]1[/SUP]Natural Product Inc., Westerville, OH, USA
[SUP]2[/SUP] School of Pharmacy and Biomedical Science, University of Portsmouth, Portsmouth, UK
Abstract
Various computational studies, including in silico ones, have identified several existing compounds that could serve as effective inhibitors of the SARS-CoV-2 main protease (M[SUP]pro[/SUP]), and thus preventing replication of the virus. Among these, rutin has been identified as a potential hit, having prominent binding affinity to the virus. Moreover, its presence in several traditional antiviral medicines prescribed in China to infected patients with mild to moderate symptoms of COVID-19 justify its promise as a repurposed bioactive secondary metabolite against SARS-CoV-2.
Keywords rutin, antiviral, main protease inhibitor, COVID-19, flavonoids, bioactivity
Article first published online: April 3, 2021; Issue published: April 1, 2021
Accepted: January 08, 2021; Received: December 28, 2020
https://doi.org/10.1177/1934578X21991723
Pawan K. Agrawal[SUP]1[/SUP], Chandan Agrawal[SUP]1[/SUP], Gerald Blunden[SUP]2[/SUP]
[SUP]1[/SUP]Natural Product Inc., Westerville, OH, USA
[SUP]2[/SUP] School of Pharmacy and Biomedical Science, University of Portsmouth, Portsmouth, UK
Abstract
Various computational studies, including in silico ones, have identified several existing compounds that could serve as effective inhibitors of the SARS-CoV-2 main protease (M[SUP]pro[/SUP]), and thus preventing replication of the virus. Among these, rutin has been identified as a potential hit, having prominent binding affinity to the virus. Moreover, its presence in several traditional antiviral medicines prescribed in China to infected patients with mild to moderate symptoms of COVID-19 justify its promise as a repurposed bioactive secondary metabolite against SARS-CoV-2.
Keywords rutin, antiviral, main protease inhibitor, COVID-19, flavonoids, bioactivity