tetano
Editor, Senior Moderator
Emerg Infect Dis. 2011 Aug;17(8):1455-62.
Risk Factors for Pandemic (H1N1) 2009 Seroconversion among Adults, Singapore, 2009.
Lim WY, Chen CH, Ma Y, Chen MI, Lee VJ, Cook AR, Tan LW, Flores Tabo N Jr, Barr I, Cui L, Lin RT, Leo YS, Chia KS.
Source
National University of Singapore, Singapore.
Abstract
A total of 828 community-dwelling adults were studied during the course of the pandemic (H1N1) 2009 outbreak in Singapore during June-September 2009. Baseline blood samples were obtained before the outbreak, and 2 additional samples were obtained during follow-up. Seroconversion was defined as a >4-fold increase in antibody titers to pandemic (H1N1) 2009, determined by using hemagglutination inhibition. Men were more likely than women to seroconvert (mean adjusted hazards ratio
2.23, mean 95% confidence interval [CI] 1.26-3.93); Malays were more likely than Chinese to seroconvert (HR 2.67, 95% CI 1.04-6.91). Travel outside Singapore during the study period was associated with seroconversion (HR 1.76, 95% CI 1.11-2.78) as was use of public transport (HR 1.81, 95% CI 1.05-3.09). High baseline antibody titers were associated with reduced seroconversion. This study suggests possible areas for intervention to reduce transmission during future influenza outbreaks.
PMID:
21801623
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/21801623
Risk Factors for Pandemic (H1N1) 2009 Seroconversion among Adults, Singapore, 2009.
Lim WY, Chen CH, Ma Y, Chen MI, Lee VJ, Cook AR, Tan LW, Flores Tabo N Jr, Barr I, Cui L, Lin RT, Leo YS, Chia KS.
Source
National University of Singapore, Singapore.
Abstract
A total of 828 community-dwelling adults were studied during the course of the pandemic (H1N1) 2009 outbreak in Singapore during June-September 2009. Baseline blood samples were obtained before the outbreak, and 2 additional samples were obtained during follow-up. Seroconversion was defined as a >4-fold increase in antibody titers to pandemic (H1N1) 2009, determined by using hemagglutination inhibition. Men were more likely than women to seroconvert (mean adjusted hazards ratio
2.23, mean 95% confidence interval [CI] 1.26-3.93); Malays were more likely than Chinese to seroconvert (HR 2.67, 95% CI 1.04-6.91). Travel outside Singapore during the study period was associated with seroconversion (HR 1.76, 95% CI 1.11-2.78) as was use of public transport (HR 1.81, 95% CI 1.05-3.09). High baseline antibody titers were associated with reduced seroconversion. This study suggests possible areas for intervention to reduce transmission during future influenza outbreaks.
PMID:
21801623
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/21801623