tetano
Editor, Senior Moderator
Rev Neurosci
. 2021 Aug 13.
doi: 10.1515/revneuro-2021-0041. Online ahead of print.
The effect of SARS-CoV-2 on the nervous system: a review of neurological impacts caused by human coronaviruses
Colin Day[SUP] 1 2 [/SUP], Carson Studders[SUP] 3 2 [/SUP], Kim Arklie[SUP] 3 2 [/SUP], Asees Kaur[SUP] 3 2 [/SUP], Kyra Teetzen[SUP] 1 2 [/SUP], Rebecca Kirsch[SUP] 4 [/SUP], Laila Abelseth[SUP] 2 [/SUP], Ian Fraser[SUP] 3 [/SUP], Emily Abelseth[SUP] 1 [/SUP], Stephanie M Willerth[SUP] 3 2 5 [/SUP]
Affiliations
Abstract
The COVID-19 pandemic has affected millions of people worldwide. While coronaviruses typically have low rates of neurotropic effects, the massive transmission of SARS-CoV-2 suggests that a substantial population will suffer from potential SARS-CoV-2-related neurological disorders. The rapid and recent emergence of SARS-CoV-2 means little research exists on its potential neurological effects. Here we analyze the effects of similar viruses to provide insight into the potential effects of SARS-CoV-2 on the nervous system and beyond. Seven coronavirus strains (HCoV-OC43, HCoV-HKU1, HCoV-229E, HCoV-NL63, SARS-CoV, MERS-CoV, SARS-CoV-2) can infect humans. Many of these strains cause neurological effects, such as headaches, dizziness, strokes, seizures, and critical illness polyneuropathy/myopathy. Certain studies have also linked coronaviruses with multiple sclerosis and extensive central nervous system injuries. Reviewing these studies provides insight into the anticipated effects for patients with SARS-CoV-2. This review will first describe the effects of other coronaviruses that have caused severe disease (SARS-CoV, MERS-CoV) on the nervous system, as well as their proposed origins, non-neurological effects, and neurological infection mechanisms. It will then discuss what is known about SARS-CoV-2 in these areas with reference to the aforementioned viruses, with the goal of providing a holistic picture of SARS-CoV-2.
Keywords: central nervous system; infection; viruses.
. 2021 Aug 13.
doi: 10.1515/revneuro-2021-0041. Online ahead of print.
The effect of SARS-CoV-2 on the nervous system: a review of neurological impacts caused by human coronaviruses
Colin Day[SUP] 1 2 [/SUP], Carson Studders[SUP] 3 2 [/SUP], Kim Arklie[SUP] 3 2 [/SUP], Asees Kaur[SUP] 3 2 [/SUP], Kyra Teetzen[SUP] 1 2 [/SUP], Rebecca Kirsch[SUP] 4 [/SUP], Laila Abelseth[SUP] 2 [/SUP], Ian Fraser[SUP] 3 [/SUP], Emily Abelseth[SUP] 1 [/SUP], Stephanie M Willerth[SUP] 3 2 5 [/SUP]
Affiliations
- PMID: 34388333
- DOI: 10.1515/revneuro-2021-0041
Abstract
The COVID-19 pandemic has affected millions of people worldwide. While coronaviruses typically have low rates of neurotropic effects, the massive transmission of SARS-CoV-2 suggests that a substantial population will suffer from potential SARS-CoV-2-related neurological disorders. The rapid and recent emergence of SARS-CoV-2 means little research exists on its potential neurological effects. Here we analyze the effects of similar viruses to provide insight into the potential effects of SARS-CoV-2 on the nervous system and beyond. Seven coronavirus strains (HCoV-OC43, HCoV-HKU1, HCoV-229E, HCoV-NL63, SARS-CoV, MERS-CoV, SARS-CoV-2) can infect humans. Many of these strains cause neurological effects, such as headaches, dizziness, strokes, seizures, and critical illness polyneuropathy/myopathy. Certain studies have also linked coronaviruses with multiple sclerosis and extensive central nervous system injuries. Reviewing these studies provides insight into the anticipated effects for patients with SARS-CoV-2. This review will first describe the effects of other coronaviruses that have caused severe disease (SARS-CoV, MERS-CoV) on the nervous system, as well as their proposed origins, non-neurological effects, and neurological infection mechanisms. It will then discuss what is known about SARS-CoV-2 in these areas with reference to the aforementioned viruses, with the goal of providing a holistic picture of SARS-CoV-2.
Keywords: central nervous system; infection; viruses.