tetano
Editor, Senior Moderator
Rev Gastroenterol Mex (Engl Ed)
. 2023 Apr 18;S2255-534X(23)00031-2.
doi: 10.1016/j.rgmxen.2023.04.002. Online ahead of print. Liver injury due to COVID-19 in critically ill adult patients. A retrospective study
N V Alva[SUP] 1 [/SUP], O R Méndez[SUP] 2 [/SUP], J C Gasca[SUP] 3 [/SUP], I Salvador[SUP] 4 [/SUP], N Hernández[SUP] 5 [/SUP], M Valdez[SUP] 6 [/SUP]
Affiliations
in English, Spanish
Introduction and aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged, causing the current pandemic of acute respiratory disease known as COVID-19. Liver injury due to COVID-19 is defined as any liver injury occurring during the course of the disease and treatment of patients with COVID-19, with or without liver disease. The incidence of elevated liver transaminases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), ranges from 2.5 to 76.3%. The aim of the present study was to describe the hepatic biochemical abnormalities, after a SARS-CoV-2-positive polymerase chain reaction (PCR) test, and the mortality rate in critically ill patients.
Materials and methods: A retrospective study was conducted that included 70 patients seen at a private hospital in Mexico City, within the time frame of February-December 2021. Median patient age was 44.5 years (range: 37-57.2) and 43 (61.4%) of the patients were men. Liver function tests were performed on the patients at hospital admission.
Results: Gamma glutamyl transferase (GGT) levels were elevated (p = 0.032), as were those of AST (p = 0.011) and ALT (p = 0.021). The patients were stratified into age groups: 18-35, 36-50, and > 50 years of age. The 18 to 35-year-olds had the highest liver enzyme levels and transaminase levels were higher, the younger the patient. Due to the low mortality rate (one patient whose death did not coincide with a hepatic cause), the multivariate analysis showed an R[SUP]2[/SUP] association of 0.689, explained by AST, GGT, and C-reactive protein levels.
Conclusions: Despite the increase in transaminases in our study population during the course of COVID-19, there was no increase in mortality. Nevertheless, hospitalized patient progression should be continuously followed.
Keywords: Acute respiratory distress syndrome; COVID-19; Lesión hepática; Liver injury; Mortalidad; Mortality; Síndrome de distrés respiratorio agudo.
. 2023 Apr 18;S2255-534X(23)00031-2.
doi: 10.1016/j.rgmxen.2023.04.002. Online ahead of print. Liver injury due to COVID-19 in critically ill adult patients. A retrospective study
N V Alva[SUP] 1 [/SUP], O R Méndez[SUP] 2 [/SUP], J C Gasca[SUP] 3 [/SUP], I Salvador[SUP] 4 [/SUP], N Hernández[SUP] 5 [/SUP], M Valdez[SUP] 6 [/SUP]
Affiliations
- PMID: 37117133
- PMCID: PMC10110936
- DOI: 10.1016/j.rgmxen.2023.04.002
in English, Spanish
Introduction and aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged, causing the current pandemic of acute respiratory disease known as COVID-19. Liver injury due to COVID-19 is defined as any liver injury occurring during the course of the disease and treatment of patients with COVID-19, with or without liver disease. The incidence of elevated liver transaminases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), ranges from 2.5 to 76.3%. The aim of the present study was to describe the hepatic biochemical abnormalities, after a SARS-CoV-2-positive polymerase chain reaction (PCR) test, and the mortality rate in critically ill patients.
Materials and methods: A retrospective study was conducted that included 70 patients seen at a private hospital in Mexico City, within the time frame of February-December 2021. Median patient age was 44.5 years (range: 37-57.2) and 43 (61.4%) of the patients were men. Liver function tests were performed on the patients at hospital admission.
Results: Gamma glutamyl transferase (GGT) levels were elevated (p = 0.032), as were those of AST (p = 0.011) and ALT (p = 0.021). The patients were stratified into age groups: 18-35, 36-50, and > 50 years of age. The 18 to 35-year-olds had the highest liver enzyme levels and transaminase levels were higher, the younger the patient. Due to the low mortality rate (one patient whose death did not coincide with a hepatic cause), the multivariate analysis showed an R[SUP]2[/SUP] association of 0.689, explained by AST, GGT, and C-reactive protein levels.
Conclusions: Despite the increase in transaminases in our study population during the course of COVID-19, there was no increase in mortality. Nevertheless, hospitalized patient progression should be continuously followed.
Keywords: Acute respiratory distress syndrome; COVID-19; Lesión hepática; Liver injury; Mortalidad; Mortality; Síndrome de distrés respiratorio agudo.