tetano
Editor, Senior Moderator
Reumatologia
. 2021;59(1):47-57.
doi: 10.5114/reum.2021.102871. Epub 2021 Feb 28.
A fine line between macrophage activation syndrome and multisystem inflammatory syndrome in children - literature review based on two case reports
Agnieszka Poniecka[SUP] 1 [/SUP], El?bieta Smolewska[SUP] 2 1 [/SUP]
Affiliations
Abstract
Multisystem inflammatory syndrome in children is a newly described condition temporarily associated with severe acute respiratory syndrome coronavirus 2. The primary observations indicated coronavirus disease 2019 infection in children to be mild. However, recent reports have revealed a correlation between multisystem inflammatory symptoms and coronavirus infection. The manifestation of the disease is similar to Kawasaki disease, toxic shock syndrome and macrophage activation syndrome. Treatment includes intravenous corticosteroids, immunoglobulin and biological therapy (anakinra, tocilizumab, infliximab). In this article we compare world reports of multisystem inflammatory syndrome in children to case reports of two patients who were hospitalized recently at the Department of Paediatric Cardiology and Rheumatology. In the course of diagnostics they presented numerous symptoms which required differentiation from multisystem inflammatory syndrome in children.
Keywords: SARS-CoV-2 infection; macrophage activation syndrome; paediatric multisystem inflammatory syndrome; secondary haemophagocytic lymphohistiocytosis.
. 2021;59(1):47-57.
doi: 10.5114/reum.2021.102871. Epub 2021 Feb 28.
A fine line between macrophage activation syndrome and multisystem inflammatory syndrome in children - literature review based on two case reports
Agnieszka Poniecka[SUP] 1 [/SUP], El?bieta Smolewska[SUP] 2 1 [/SUP]
Affiliations
- PMID: 33707796
- PMCID: PMC7944956
- DOI: 10.5114/reum.2021.102871
Abstract
Multisystem inflammatory syndrome in children is a newly described condition temporarily associated with severe acute respiratory syndrome coronavirus 2. The primary observations indicated coronavirus disease 2019 infection in children to be mild. However, recent reports have revealed a correlation between multisystem inflammatory symptoms and coronavirus infection. The manifestation of the disease is similar to Kawasaki disease, toxic shock syndrome and macrophage activation syndrome. Treatment includes intravenous corticosteroids, immunoglobulin and biological therapy (anakinra, tocilizumab, infliximab). In this article we compare world reports of multisystem inflammatory syndrome in children to case reports of two patients who were hospitalized recently at the Department of Paediatric Cardiology and Rheumatology. In the course of diagnostics they presented numerous symptoms which required differentiation from multisystem inflammatory syndrome in children.
Keywords: SARS-CoV-2 infection; macrophage activation syndrome; paediatric multisystem inflammatory syndrome; secondary haemophagocytic lymphohistiocytosis.