tetano
Editor, Senior Moderator
Retina
. 2023 Oct 9.
doi: 10.1097/IAE.0000000000003952. Online ahead of print. Retinal Vascular Occlusion and COVID-19 Diagnosis: A Multicenter Population-based Study
Jing-Xing Li[SUP] 1 2 3 [/SUP], James Cheng-Chung Wei[SUP] 4 5 6 7 [/SUP], Yu-Hsun Wang[SUP] 4 [/SUP], Henry Bair[SUP] 8 9 [/SUP], Shu-Bai Hsu[SUP] 10 11 [/SUP], Chun-Ju Lin[SUP] 2 8 12 [/SUP]
Affiliations
Introduction: Several ocular diseases have been reported in patients with coronavirus disease 2019 (COVID-19), especially retinal vascular occlusion. This study aims to examine the risk of retinal vascular occlusion following COVID-19 diagnosis.
Method: This retrospective cohort study was based on 46 healthcare organizations in the United States using the TriNetX network. Individuals who had laboratory confirmation of COVID-19 from January 1, 2020 to December 31, 2021 were included. Multivariate analysis was adjusted on age, sex, race and comorbidities, and hazard ratio was calculated by Cox proportional hazard regression model.
Results: 1,460,634 paired individuals were enrolled for analysis. Patients with COVID-19 had a significantly higher risk of branch retinal vein occlusion (BRVO) (hazard ratio
1.27, 95% confidence interval [CI] 1.04-1.52) than those without COVID-19. The cumulative incidence rate of BRVO was also significantly higher in patients with COVID-19 compared with those without COVID-19 (log-rank p = 0.014). Within 12 weeks following COVID-19 diagnosis, transient effect of central retinal vein occlusion (HR 1.59, 95% CI 1.15-2.17) and BRVO (HR 2.11, 95% CI 1.51-2.95) were observed.
Conclusions: This large-scale multicenter study demonstrated retinal vein occlusion may be associated with COVID-19.
. 2023 Oct 9.
doi: 10.1097/IAE.0000000000003952. Online ahead of print. Retinal Vascular Occlusion and COVID-19 Diagnosis: A Multicenter Population-based Study
Jing-Xing Li[SUP] 1 2 3 [/SUP], James Cheng-Chung Wei[SUP] 4 5 6 7 [/SUP], Yu-Hsun Wang[SUP] 4 [/SUP], Henry Bair[SUP] 8 9 [/SUP], Shu-Bai Hsu[SUP] 10 11 [/SUP], Chun-Ju Lin[SUP] 2 8 12 [/SUP]
Affiliations
- PMID: 37824812
- DOI: 10.1097/IAE.0000000000003952
Introduction: Several ocular diseases have been reported in patients with coronavirus disease 2019 (COVID-19), especially retinal vascular occlusion. This study aims to examine the risk of retinal vascular occlusion following COVID-19 diagnosis.
Method: This retrospective cohort study was based on 46 healthcare organizations in the United States using the TriNetX network. Individuals who had laboratory confirmation of COVID-19 from January 1, 2020 to December 31, 2021 were included. Multivariate analysis was adjusted on age, sex, race and comorbidities, and hazard ratio was calculated by Cox proportional hazard regression model.
Results: 1,460,634 paired individuals were enrolled for analysis. Patients with COVID-19 had a significantly higher risk of branch retinal vein occlusion (BRVO) (hazard ratio
1.27, 95% confidence interval [CI] 1.04-1.52) than those without COVID-19. The cumulative incidence rate of BRVO was also significantly higher in patients with COVID-19 compared with those without COVID-19 (log-rank p = 0.014). Within 12 weeks following COVID-19 diagnosis, transient effect of central retinal vein occlusion (HR 1.59, 95% CI 1.15-2.17) and BRVO (HR 2.11, 95% CI 1.51-2.95) were observed.
Conclusions: This large-scale multicenter study demonstrated retinal vein occlusion may be associated with COVID-19.