tetano
Editor, Senior Moderator
Respiration
. 2022 Dec 23;1-14.
doi: 10.1159/000528611. Online ahead of print.
Pulmonary Recovery 12 Months after Non-Severe and Severe COVID-19: The Prospective Swiss COVID-19 Lung Study
Alexandra Lenoir[SUP] 1 2 [/SUP], Andreas Christe[SUP] 3 [/SUP], Lukas Ebner[SUP] 3 [/SUP], Catherine Beigelman-Aubry[SUP] 4 [/SUP], Pierre-Olivier Bridevaux[SUP] 5 [/SUP], Martin Brutsche[SUP] 6 [/SUP], Christian Clarenbach[SUP] 7 [/SUP], Berra Erkosar[SUP] 8 [/SUP], Christian Garzoni[SUP] 9 10 [/SUP], Thomas Geiser[SUP] 11 12 [/SUP], Sabina A Guler[SUP] 11 12 [/SUP], Dik Heg[SUP] 13 [/SUP], Frédéric Lador[SUP] 14 [/SUP], Marco Mancinetti[SUP] 15 [/SUP], Sebastian R Ott[SUP] 16 17 [/SUP], Lise Piquilloud[SUP] 18 [/SUP], Maura Prella[SUP] 8 [/SUP], Yok-Ai Que[SUP] 19 [/SUP], Christophe von Garnier[SUP] 8 [/SUP], Manuela Funke-Chambour[SUP] 11 12 [/SUP]
Affiliations
Abstract
Background: Lung function impairment persists in some patients for months after acute coronavirus disease 2019 (COVID-19). Long-term lung function, radiological features, and their association remain to be clarified.
Objectives: We aimed to prospectively investigate lung function and radiological abnormalities over 12 months after severe and non-severe COVID-19.
Methods: 584 patients were included in the Swiss COVID-19 lung study. We assessed lung function at 3, 6, and 12 months after acute COVID-19 and compared chest computed tomography (CT) imaging to lung functional abnormalities.
Results: At 12 months, diffusion capacity for carbon monoxide (DLCOcorr) was lower after severe COVID-19 compared to non-severe COVID-19 (74.9% vs. 85.2% predicted, p < 0.001). Similarly, minimal oxygen saturation on 6-min walk test and total lung capacity were lower after severe COVID-19 (89.6% vs. 92.2%, p = 0.004, respectively, 88.2% vs. 95.1% predicted, p = 0.011). The difference for forced vital capacity (91.6% vs. 96.3% predicted, p = 0.082) was not statistically significant. Between 3 and 12 months, lung function improved in both groups and differences in DLCO between non-severe and severe COVID-19 patients decreased. In patients with chest CT scans at 12 months, we observed a correlation between radiological abnormalities and reduced lung function. While the overall extent of radiological abnormalities diminished over time, the frequency of mosaic attenuation and curvilinear patterns increased.
Conclusions: In this prospective cohort study, patients who had severe COVID-19 had diminished lung function over the first year compared to those after non-severe COVID-19, albeit with a greater extent of recovery in the severe disease group.
Keywords: COVID-19 sequelae; Long COVID; SARS-CoV-2; SARS-CoV-2 lung functional sequelae; SARS-CoV-2 radiological sequelae.
. 2022 Dec 23;1-14.
doi: 10.1159/000528611. Online ahead of print.
Pulmonary Recovery 12 Months after Non-Severe and Severe COVID-19: The Prospective Swiss COVID-19 Lung Study
Alexandra Lenoir[SUP] 1 2 [/SUP], Andreas Christe[SUP] 3 [/SUP], Lukas Ebner[SUP] 3 [/SUP], Catherine Beigelman-Aubry[SUP] 4 [/SUP], Pierre-Olivier Bridevaux[SUP] 5 [/SUP], Martin Brutsche[SUP] 6 [/SUP], Christian Clarenbach[SUP] 7 [/SUP], Berra Erkosar[SUP] 8 [/SUP], Christian Garzoni[SUP] 9 10 [/SUP], Thomas Geiser[SUP] 11 12 [/SUP], Sabina A Guler[SUP] 11 12 [/SUP], Dik Heg[SUP] 13 [/SUP], Frédéric Lador[SUP] 14 [/SUP], Marco Mancinetti[SUP] 15 [/SUP], Sebastian R Ott[SUP] 16 17 [/SUP], Lise Piquilloud[SUP] 18 [/SUP], Maura Prella[SUP] 8 [/SUP], Yok-Ai Que[SUP] 19 [/SUP], Christophe von Garnier[SUP] 8 [/SUP], Manuela Funke-Chambour[SUP] 11 12 [/SUP]
Affiliations
- PMID: 36566741
- DOI: 10.1159/000528611
Abstract
Background: Lung function impairment persists in some patients for months after acute coronavirus disease 2019 (COVID-19). Long-term lung function, radiological features, and their association remain to be clarified.
Objectives: We aimed to prospectively investigate lung function and radiological abnormalities over 12 months after severe and non-severe COVID-19.
Methods: 584 patients were included in the Swiss COVID-19 lung study. We assessed lung function at 3, 6, and 12 months after acute COVID-19 and compared chest computed tomography (CT) imaging to lung functional abnormalities.
Results: At 12 months, diffusion capacity for carbon monoxide (DLCOcorr) was lower after severe COVID-19 compared to non-severe COVID-19 (74.9% vs. 85.2% predicted, p < 0.001). Similarly, minimal oxygen saturation on 6-min walk test and total lung capacity were lower after severe COVID-19 (89.6% vs. 92.2%, p = 0.004, respectively, 88.2% vs. 95.1% predicted, p = 0.011). The difference for forced vital capacity (91.6% vs. 96.3% predicted, p = 0.082) was not statistically significant. Between 3 and 12 months, lung function improved in both groups and differences in DLCO between non-severe and severe COVID-19 patients decreased. In patients with chest CT scans at 12 months, we observed a correlation between radiological abnormalities and reduced lung function. While the overall extent of radiological abnormalities diminished over time, the frequency of mosaic attenuation and curvilinear patterns increased.
Conclusions: In this prospective cohort study, patients who had severe COVID-19 had diminished lung function over the first year compared to those after non-severe COVID-19, albeit with a greater extent of recovery in the severe disease group.
Keywords: COVID-19 sequelae; Long COVID; SARS-CoV-2; SARS-CoV-2 lung functional sequelae; SARS-CoV-2 radiological sequelae.