tetano
Editor, Senior Moderator
Respir Res
. 2020 Jul 22;21(1):194.
doi: 10.1186/s12931-020-01455-4.
Continuously available ratio of SpO [SUB]2[/SUB]/FiO [SUB]2[/SUB] serves as a noninvasive prognostic marker for intensive care patients with COVID-19
Xiaofan Lu[SUP] 1 [/SUP], Liyun Jiang[SUP] 1 2 [/SUP], Taige Chen[SUP] 3 [/SUP], Yang Wang[SUP] 4 [/SUP], Bing Zhang[SUP] 4 [/SUP], Yizhou Hong[SUP] 1 [/SUP], Jun Wang[SUP] 5 [/SUP], Fangrong Yan[SUP] 6 [/SUP]
Affiliations
Abstract
Rationale: Oxygen saturation to fraction of inspired oxygen ratio (SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB]) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though.
Methods: Prognostic value of SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] was evaluated by jointly modeling the longitudinal responses of SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19.
Results: A sharply decrease of SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] from the first to second measurement for non-survivors was observed, and a strong association between square root SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56-2.13).
Conclusions: The current study suggested that SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival.
Keywords: COVID-19; Joint model; Prognostic marker; SpO2/FiO2.
. 2020 Jul 22;21(1):194.
doi: 10.1186/s12931-020-01455-4.
Continuously available ratio of SpO [SUB]2[/SUB]/FiO [SUB]2[/SUB] serves as a noninvasive prognostic marker for intensive care patients with COVID-19
Xiaofan Lu[SUP] 1 [/SUP], Liyun Jiang[SUP] 1 2 [/SUP], Taige Chen[SUP] 3 [/SUP], Yang Wang[SUP] 4 [/SUP], Bing Zhang[SUP] 4 [/SUP], Yizhou Hong[SUP] 1 [/SUP], Jun Wang[SUP] 5 [/SUP], Fangrong Yan[SUP] 6 [/SUP]
Affiliations
- PMID: 32698822
- DOI: 10.1186/s12931-020-01455-4
Abstract
Rationale: Oxygen saturation to fraction of inspired oxygen ratio (SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB]) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though.
Methods: Prognostic value of SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] was evaluated by jointly modeling the longitudinal responses of SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19.
Results: A sharply decrease of SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] from the first to second measurement for non-survivors was observed, and a strong association between square root SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56-2.13).
Conclusions: The current study suggested that SpO[SUB]2[/SUB]/FiO[SUB]2[/SUB] could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival.
Keywords: COVID-19; Joint model; Prognostic marker; SpO2/FiO2.