tetano
Editor, Senior Moderator
Respir Res
. 2021 Mar 3;22(1):76.
doi: 10.1186/s12931-021-01666-3.
Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients
Alberto Ricci[SUP] 1 2 [/SUP], Alessandra Pagliuca[SUP] 1 2 [/SUP], Michela D'Ascanio[SUP] 1 2 [/SUP], Marta Innammorato[SUP] 3 4 [/SUP], Claudia De Vitis[SUP] 2 [/SUP], Rita Mancini[SUP] 2 [/SUP], Simonetta Giovagnoli[SUP] 2 [/SUP], Francesco Facchiano[SUP] 5 [/SUP], Bruno Sposato[SUP] 6 [/SUP], Paolo Anibaldi[SUP] 2 [/SUP], Adriano Marcolongo[SUP] 2 [/SUP], Chiara De Dominicis[SUP] 2 [/SUP], Andrea Laghi[SUP] 2 [/SUP], Emanuele Muscogiuri[SUP] 2 [/SUP], Salvatore Sciacchitano[SUP] 1 7 [/SUP]
Affiliations
Abstract
Background: Several immune mechanisms activate in COVID-19 pathogenesis. Usually, coronavirus infection is characterized by dysregulated host immune responses, interleukine-6 increase, hyper-activation of cytotoxic CD8 T lymphocytes. Interestingly, Vitamin D deficiency has been often associated with altered immune responses and infections. In the present study, we evaluated Vitamin D plasma levels in patients affected with different lung involvement during COVID-19 infection.
Methods: Lymphocyte phenotypes were assessed by flow cytometry. Thoracic CT scan involvement was obtained by an image analysis program.
Results: Vitamin D levels were deficient in (80%) of patients, insufficient in (6.5%) and normal in (13.5%). Patients with very low Vitamin D plasma levels had more elevated D-Dimer values, a more elevated B lymphocyte cell count, a reduction of CD8 + T lymphocytes with a low CD4/CD8 ratio, more compromised clinical findings (measured by LIPI and SOFA scores) and thoracic CT scan involvement.
Conclusions: Vitamin D deficiency is associated with compromised inflammatory responses and higher pulmonary involvement in COVID-19 affected patients. Vitamin D assessment, during COVID-19 infection, could be a useful analysis for possible therapeutic interventions.
Trial registration: 'retrospectively registered'.
. 2021 Mar 3;22(1):76.
doi: 10.1186/s12931-021-01666-3.
Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients
Alberto Ricci[SUP] 1 2 [/SUP], Alessandra Pagliuca[SUP] 1 2 [/SUP], Michela D'Ascanio[SUP] 1 2 [/SUP], Marta Innammorato[SUP] 3 4 [/SUP], Claudia De Vitis[SUP] 2 [/SUP], Rita Mancini[SUP] 2 [/SUP], Simonetta Giovagnoli[SUP] 2 [/SUP], Francesco Facchiano[SUP] 5 [/SUP], Bruno Sposato[SUP] 6 [/SUP], Paolo Anibaldi[SUP] 2 [/SUP], Adriano Marcolongo[SUP] 2 [/SUP], Chiara De Dominicis[SUP] 2 [/SUP], Andrea Laghi[SUP] 2 [/SUP], Emanuele Muscogiuri[SUP] 2 [/SUP], Salvatore Sciacchitano[SUP] 1 7 [/SUP]
Affiliations
- PMID: 33658032
- DOI: 10.1186/s12931-021-01666-3
Abstract
Background: Several immune mechanisms activate in COVID-19 pathogenesis. Usually, coronavirus infection is characterized by dysregulated host immune responses, interleukine-6 increase, hyper-activation of cytotoxic CD8 T lymphocytes. Interestingly, Vitamin D deficiency has been often associated with altered immune responses and infections. In the present study, we evaluated Vitamin D plasma levels in patients affected with different lung involvement during COVID-19 infection.
Methods: Lymphocyte phenotypes were assessed by flow cytometry. Thoracic CT scan involvement was obtained by an image analysis program.
Results: Vitamin D levels were deficient in (80%) of patients, insufficient in (6.5%) and normal in (13.5%). Patients with very low Vitamin D plasma levels had more elevated D-Dimer values, a more elevated B lymphocyte cell count, a reduction of CD8 + T lymphocytes with a low CD4/CD8 ratio, more compromised clinical findings (measured by LIPI and SOFA scores) and thoracic CT scan involvement.
Conclusions: Vitamin D deficiency is associated with compromised inflammatory responses and higher pulmonary involvement in COVID-19 affected patients. Vitamin D assessment, during COVID-19 infection, could be a useful analysis for possible therapeutic interventions.
Trial registration: 'retrospectively registered'.