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Research on enhanced transmissibility in H5N1 influenza: Should the moratorium end?

tetano

Editor, Senior Moderator
How can scientists safely conduct avian flu research if the results could potentially threaten, as well as save, millions of lives? In a series of commentaries appearing on Tuesday, October 9 in mBio, the online open-access journal of the American Society for Microbiology, prominent microbiologists and physicians argue the cases both for and against lifting a voluntary moratorium on experiments to enhance the ability of the H5N1 virus to move from mammal to mammal, so-called "gain-of-function" research, and discuss the level of biosecurity that would be appropriate for moving that research forward.

In January 2012, in response to the controversy caused by the unprecedented recommendation iof an advisory board to the government to redact methods sections of two research studies showing how genetic changes could make H5N1 become transmissible between mammals, a group of influenza researchers agreed to a voluntary pause on any research involving highly pathogenic avian influenza H5N1 viruses leading to the generation of viruses that are more transmissible in mammals. Despite both articles eventually being published in full in May and June 2012, the research moratorium remains in place.

"The scientific community and the greater society that it serves are currently engaged in a vigorous debate on whether and how to carry out experiments that could provide essential information for preparedness against a pandemic of avian influenza. To foster discussion and to provide a venue to record the arguments for or against this moratorium, mBio has commissioned a series of views from experts in the field," write Arturo Casadevall of the Albert Einstein School of Medicine, editor-in-chief of mBio; and Thomas Shenk of Princeton University, Chair of the ASM Publications Board, in an introductory editorial.

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http://m.medicalxpress.com/news/2012-10-transmissibility-h5n1-influenza-moratorium.html
 
Re: Research on enhanced transmissibility in H5N1 influenza: Should the moratorium end?

The Lessons of Asilomar and the H5N1 “Affair”

Stanley Falkow

doi:10.1128/mBio.00354-12

http://mbio.asm.org/content/3/5/e00354-12



The H5N1 Moratorium Controversy and Debate

Arturo Casadevall and Thomas Shenk

doi:10.1128/mBio.00379-12

http://mbio.asm.org/content/3/5/e00379-12The H5N1 Moratorium Controversy and Debate




Research on Highly Pathogenic H5N1 Influenza Virus: The Way Forward

Anthony S. Fauci

doi:10.1128/mBio.00359-12

http://mbio.asm.org/content/3/5/e00359-12



Rethinking Biosafety in Research on Potential Pandemic Pathogens


Marc Lipsitch and Barry R. Bloom

doi:10.1128/mBio.00360-12

http://mbio.asm.org/content/3/5/e00360-12



The Pause on Avian H5N1 Influenza Virus Transmission Research Should Be Ended

Ron A. M. Fouchier, Adolfo García-Sastre and Yoshihiro Kawaoka

doi:10.1128/mBio.00358-12

http://mbio.asm.org/content/3/5/e00358-12
 
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