tetano
Editor, Senior Moderator
Res Social Adm Pharm
. 2022 Jul 16;S1551-7411(22)00208-X.
doi: 10.1016/j.sapharm.2022.07.004. Online ahead of print.
Thromboprophylaxis and clinical outcomes in moderate COVID-19 patients: A comparative study
Asmaa S Mohamed[SUP] 1 [/SUP], Hosam M Ahmad[SUP] 2 [/SUP], Alyaa S A Abdul-Raheem[SUP] 3 [/SUP], Fatma M M Kamel[SUP] 4 [/SUP], Ali Khames[SUP] 5 [/SUP], Ahmed F Mady[SUP] 6 [/SUP]
Affiliations
Abstract
Background: Many thrombotic complications are linked to coronavirus disease 2019 (COVID-19). Antithrombotic treatments are important for prophylaxis against these thrombotic events.
Objectives: This study was designed to compare enoxaparin and rivaroxaban as prophylactic anticoagulants in moderate cases of COVID-19 in terms of efficacy, safety, and clinical outcomes.
Methods: The study involved 124 patients with moderate COVID-19 (pneumonia without hypoxia) divided into two groups. The first group (G1) comprised 66 patients who received enoxaparin subcutaneously at a dose of 0.5 mg/kg every 12 h until discharge from the hospital. The second group (G2) comprised 58 patients who received oral rivaroxaban at a dose of 10 mg once daily until discharge from the hospital. The outcomes evaluated in this study were as follows: intermediate care unit (IMCU) duration, the number of patients transferred from the IMCU to the intensive care unit (ICU), ICU duration, the total length of hospital stay, in-hospital mortality, and thrombotic and bleeding complications.
Results: No significant differences in IMCU duration (p = 0.39), ICU duration (p = 0.96), and total length of hospital stay (p = 0.73) were observed between the two groups. The percentage of patients requiring ICU admission after hospitalization was 21.2% in G1 and 22.4% in G2 (p = 0.87). The mortality rate was 12.1% in G1 and 10.3% in G2 (p = 0.76). The proportion of patients who had thrombotic complications was 9.1% in G1 and 12.1% in G2 (p = 0.59). The incidence of mild bleeding was 3% in G1 and 1.7% in G2 (p = 0.64).
Conclusion: Either enoxaparin or rivaroxaban may be used as thromboprophylaxis agents in managing patients with moderate COVID-19. Either medication has no clear advantage over the other.
Keywords: Anticoagulants; COVID-19; Enoxaparin; Rivaroxaban; Thromboprophylaxis.
. 2022 Jul 16;S1551-7411(22)00208-X.
doi: 10.1016/j.sapharm.2022.07.004. Online ahead of print.
Thromboprophylaxis and clinical outcomes in moderate COVID-19 patients: A comparative study
Asmaa S Mohamed[SUP] 1 [/SUP], Hosam M Ahmad[SUP] 2 [/SUP], Alyaa S A Abdul-Raheem[SUP] 3 [/SUP], Fatma M M Kamel[SUP] 4 [/SUP], Ali Khames[SUP] 5 [/SUP], Ahmed F Mady[SUP] 6 [/SUP]
Affiliations
- PMID: 35864037
- DOI: 10.1016/j.sapharm.2022.07.004
Abstract
Background: Many thrombotic complications are linked to coronavirus disease 2019 (COVID-19). Antithrombotic treatments are important for prophylaxis against these thrombotic events.
Objectives: This study was designed to compare enoxaparin and rivaroxaban as prophylactic anticoagulants in moderate cases of COVID-19 in terms of efficacy, safety, and clinical outcomes.
Methods: The study involved 124 patients with moderate COVID-19 (pneumonia without hypoxia) divided into two groups. The first group (G1) comprised 66 patients who received enoxaparin subcutaneously at a dose of 0.5 mg/kg every 12 h until discharge from the hospital. The second group (G2) comprised 58 patients who received oral rivaroxaban at a dose of 10 mg once daily until discharge from the hospital. The outcomes evaluated in this study were as follows: intermediate care unit (IMCU) duration, the number of patients transferred from the IMCU to the intensive care unit (ICU), ICU duration, the total length of hospital stay, in-hospital mortality, and thrombotic and bleeding complications.
Results: No significant differences in IMCU duration (p = 0.39), ICU duration (p = 0.96), and total length of hospital stay (p = 0.73) were observed between the two groups. The percentage of patients requiring ICU admission after hospitalization was 21.2% in G1 and 22.4% in G2 (p = 0.87). The mortality rate was 12.1% in G1 and 10.3% in G2 (p = 0.76). The proportion of patients who had thrombotic complications was 9.1% in G1 and 12.1% in G2 (p = 0.59). The incidence of mild bleeding was 3% in G1 and 1.7% in G2 (p = 0.64).
Conclusion: Either enoxaparin or rivaroxaban may be used as thromboprophylaxis agents in managing patients with moderate COVID-19. Either medication has no clear advantage over the other.
Keywords: Anticoagulants; COVID-19; Enoxaparin; Rivaroxaban; Thromboprophylaxis.