tetano
Editor, Senior Moderator
Biochem Biophys Res Commun. 2013 Oct 28. pii: S0006-291X(13)01781-6. doi: 10.1016/j.bbrc.2013.10.100. [Epub ahead of print]
Relevance of signaling molecules for apoptosis induction on influenza A virus replication.
Iwai A, Shiozaki T, Miyazaki T.
Source
Aureo Science Co., Ltd., North 21, West 12, Kita-Ku, Sapporo, Hokkaido 001-0021, Japan.
Abstract
Apoptosis is an important mechanism to maintain homeostasis in mammals, and disruption of the apoptosis regulation mechanism triggers a range of diseases, such as cancer, autoimmune diseases, and developmental disorders. The severity of influenza A virus (IAV) infection is also closely related to dysfunction of apoptosis regulation. In the virus infected cells, the functions of various host cellular molecules involved in regulation of induction of apoptosis are modulated by IAV proteins to enable effective virus replication. The modulation of the intracellular signaling pathway inducing apoptosis by the IAV infection also affects extracellular mechanisms controling apoptosis, and triggers abnormal host responses related to the disease severity of IAV infections. This review focuses on apoptosis related molecules involved in IAV replication and pathogenicity, the strategy of the virus propagation through the regulation of apoptosis is also discussed.
Copyright ? 2013. Published by Elsevier Inc.
KEYWORDS:
Akt, Apaf-1, Apoptotic protease activating factor 1, B-cell lymphoma 2, BH, Bax, Bcl-2, Bcl-2 homology, Bcl-2-associated x protein, DAP3, DR4, DR5, FADD, Fas-associated death domain, IAV, IFN, IFN regulatory factor 3, INF-β promoter stimulator protein 1, IPS-1, IRF3, Influenza A virus, JNK, M, Matrix protein, NA, NF-κB, NP, NS1, PI3K, RIG-I, TNF-related apoptosis inducing ligand, TNF-α, TNF-α receptor 1, TNFαR1, TRADD, TRAIL, Tumor necrosis factor receptor type 1-associated death domain protein, X-linked inhibitor of apoptosis protein, XIAP, ZAPS, apoptosis, c-Jun amino-terminal kinase, caspases, cysteine-aspartic acid protease, death receptor 4, death receptor 5, death-associated protein 3, influenza A virus, interferon, neuraminidase, non-structural protein 1, nuclear factor-κB, nucleoprotein, phosphatidylinositol-3 kinase, retinoic acid-inducible gene-I, signal transduction, tumor necrosis factor α, v-akt murine thymoma viral oncogene homolog 1, zinc finger antiviral protein, short form
PMID:
24177013
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24177013
Relevance of signaling molecules for apoptosis induction on influenza A virus replication.
Iwai A, Shiozaki T, Miyazaki T.
Source
Aureo Science Co., Ltd., North 21, West 12, Kita-Ku, Sapporo, Hokkaido 001-0021, Japan.
Abstract
Apoptosis is an important mechanism to maintain homeostasis in mammals, and disruption of the apoptosis regulation mechanism triggers a range of diseases, such as cancer, autoimmune diseases, and developmental disorders. The severity of influenza A virus (IAV) infection is also closely related to dysfunction of apoptosis regulation. In the virus infected cells, the functions of various host cellular molecules involved in regulation of induction of apoptosis are modulated by IAV proteins to enable effective virus replication. The modulation of the intracellular signaling pathway inducing apoptosis by the IAV infection also affects extracellular mechanisms controling apoptosis, and triggers abnormal host responses related to the disease severity of IAV infections. This review focuses on apoptosis related molecules involved in IAV replication and pathogenicity, the strategy of the virus propagation through the regulation of apoptosis is also discussed.
Copyright ? 2013. Published by Elsevier Inc.
KEYWORDS:
Akt, Apaf-1, Apoptotic protease activating factor 1, B-cell lymphoma 2, BH, Bax, Bcl-2, Bcl-2 homology, Bcl-2-associated x protein, DAP3, DR4, DR5, FADD, Fas-associated death domain, IAV, IFN, IFN regulatory factor 3, INF-β promoter stimulator protein 1, IPS-1, IRF3, Influenza A virus, JNK, M, Matrix protein, NA, NF-κB, NP, NS1, PI3K, RIG-I, TNF-related apoptosis inducing ligand, TNF-α, TNF-α receptor 1, TNFαR1, TRADD, TRAIL, Tumor necrosis factor receptor type 1-associated death domain protein, X-linked inhibitor of apoptosis protein, XIAP, ZAPS, apoptosis, c-Jun amino-terminal kinase, caspases, cysteine-aspartic acid protease, death receptor 4, death receptor 5, death-associated protein 3, influenza A virus, interferon, neuraminidase, non-structural protein 1, nuclear factor-κB, nucleoprotein, phosphatidylinositol-3 kinase, retinoic acid-inducible gene-I, signal transduction, tumor necrosis factor α, v-akt murine thymoma viral oncogene homolog 1, zinc finger antiviral protein, short form
PMID:
24177013
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24177013