Reduced evolutionary rate in reemerged Ebola virus transmission chains

[sharon sanders]

Reduced evolutionary rate in reemerged Ebola virus transmission chains

• David J. Blackley1,*,
• Michael R. Wiley2,*,
• Jason T. Ladner2,*,
• Mosoka Fallah3,*,
• Terrence Lo1,
• Merle L. Gilbert2,
• Christopher Gregory1,
• Jonathan D’ambrozio2,
• Stewart Coulter1,
• Suzanne Mate2,
• Zephaniah Balogun1,
• Jeffrey Kugelman2,
• William Nwachukwu1,
• Karla Prieto2,
• Adolphus Yeiah3,
• Fred Amegashie3,
• Brian Kearney2,
• Meagan Wisniewski2,
• John Saindon1,
• Gary Schroth4,
• Lawrence Fakoli5,
• Joseph W. Diclaro II6,
• Jens H. Kuhn7,
• Lisa E. Hensley7,
• Peter B. Jahrling7,
• Ute Str?her1,
• Stuart T. Nichol1,
• Moses Massaquoi3,
• Francis Kateh3,
• Peter Clement8,
• Alex Gasasira8,
• Fatorma Bolay5,
• Stephan S. Monroe1,
• Andrew Rambaut9,10,11,
• Mariano Sanchez-Lockhart2,
• A. Scott Laney1,
• Tolbert Nyenswah3,†,
• Athalia Christie1,† and
• Gustavo Palacios2,†

+ Author Affiliations

• ↵†Corresponding author. Email: gustavo.f.palacios.ctr@mail.mil (G.P.); akc9@cdc.gov (A.C.); tgnyenswah74@yahoo.com(T.N.)

• ↵* These authors contributed equally to this work.

Science Advances 29 Apr 2016:
Vol. 2, no. 4, e1600378
DOI: 10.1126/sciadv.1600378

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Using this rate of change as a signature, we identified two additional EVD clusters that possibly arose from persistently infected sources. These findings highlight the risk of EVD flare-ups even after an outbreak is declared over.

http://advances.sciencemag.org/content/2/4/e1600378