tetano
Editor, Senior Moderator
Mini Rev Med Chem. 2012 Feb 3. [Epub ahead of print]
Recent advances in computational studies on influenza a virus M2 proton channel.
Wang JF, Chou KC.
Source
Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Abstract
The matrix protein 2 of the influenza A virus (M2 or AM2) is one of the important components of the viral membrane. This protein can form a proton channel in the viral envelope. Owe to its ability to regulate the surrounding pH in endosome, this protein is an attractive target for drug design against influenza A virus. In this minireview, we are to summarize the current progresses in computational approaches for studying the M2 proton channel. The attention is focused on how protons are conducted through the M2 channel, and how adamantane-based drugs inhibit the channel, as well as how the drug resistance occurs, in hopes to further stimulate the in-depth studies of this important area, both experimentally and theoretically.
PMID:
22303978
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22303978
Recent advances in computational studies on influenza a virus M2 proton channel.
Wang JF, Chou KC.
Source
Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Abstract
The matrix protein 2 of the influenza A virus (M2 or AM2) is one of the important components of the viral membrane. This protein can form a proton channel in the viral envelope. Owe to its ability to regulate the surrounding pH in endosome, this protein is an attractive target for drug design against influenza A virus. In this minireview, we are to summarize the current progresses in computational approaches for studying the M2 proton channel. The attention is focused on how protons are conducted through the M2 channel, and how adamantane-based drugs inhibit the channel, as well as how the drug resistance occurs, in hopes to further stimulate the in-depth studies of this important area, both experimentally and theoretically.
PMID:
22303978
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22303978