tetano
Editor, Senior Moderator
Vaccine. 2018 Feb 15. pii: S0264-410X(18)30201-9. doi: 10.1016/j.vaccine.2018.02.027. [Epub ahead of print]
[h=1]Quantitative profiling reveals minor changes of T cell receptor repertoire in response to subunit inactivated influenza vaccine.[/h] Sycheva AL[SUP]1[/SUP], Pogorelyy MV[SUP]1[/SUP], Komech EA[SUP]2[/SUP], Minervina AA[SUP]1[/SUP], Zvyagin IV[SUP]2[/SUP], Staroverov DB[SUP]2[/SUP], Chudakov DM[SUP]3[/SUP], Lebedev YB[SUP]2[/SUP], Mamedov IZ[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Vaccination against influenza is widely used to protect against seasonal flu epidemic although its effectiveness is debated. Here we performed deep quantitative T cell receptor repertoire profiling in peripheral blood of a healthy volunteer in response to trivalent subunit influenza vaccine. We did not observe significant rebuilding of peripheral blood T cell receptors composition in response to vaccination. However, we found several clonotypes in memory T cell fraction that were undetectable before the vaccination and had a maximum concentration at day 45 after vaccine administration. These cells were found in lower concentration in the course of repertoire monitoring for two years period. Our observation suggests a potential for recruitment of only a limited number of new T cells after each seasonal influenza vaccination.
[h=4]KEYWORDS:[/h] High-throughput sequencing; Inactivated influenza vaccine; T cell receptor; TCR repertoires
PMID: 29454515 DOI: 10.1016/j.vaccine.2018.02.027
[h=1]Quantitative profiling reveals minor changes of T cell receptor repertoire in response to subunit inactivated influenza vaccine.[/h] Sycheva AL[SUP]1[/SUP], Pogorelyy MV[SUP]1[/SUP], Komech EA[SUP]2[/SUP], Minervina AA[SUP]1[/SUP], Zvyagin IV[SUP]2[/SUP], Staroverov DB[SUP]2[/SUP], Chudakov DM[SUP]3[/SUP], Lebedev YB[SUP]2[/SUP], Mamedov IZ[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Vaccination against influenza is widely used to protect against seasonal flu epidemic although its effectiveness is debated. Here we performed deep quantitative T cell receptor repertoire profiling in peripheral blood of a healthy volunteer in response to trivalent subunit influenza vaccine. We did not observe significant rebuilding of peripheral blood T cell receptors composition in response to vaccination. However, we found several clonotypes in memory T cell fraction that were undetectable before the vaccination and had a maximum concentration at day 45 after vaccine administration. These cells were found in lower concentration in the course of repertoire monitoring for two years period. Our observation suggests a potential for recruitment of only a limited number of new T cells after each seasonal influenza vaccination.
[h=4]KEYWORDS:[/h] High-throughput sequencing; Inactivated influenza vaccine; T cell receptor; TCR repertoires
PMID: 29454515 DOI: 10.1016/j.vaccine.2018.02.027