tetano
Editor, Senior Moderator
Public Health
. 2021 May 5;195:123-125.
doi: 10.1016/j.puhe.2021.04.023. Online ahead of print.
Survival in adult pneumonia inpatients fulfilling suspected COVID-19 criteria and baseline negative RT-qPCR
E Murillo-Zamora[SUP] 1 [/SUP], O Mendoza-Cano[SUP] 2 [/SUP], M I Cárdenas-Rojas[SUP] 3 [/SUP], C M Hernandez-Suarez[SUP] 4 [/SUP], J Guzmán-Esquivel[SUP] 5 [/SUP]
Affiliations
Abstract
Objectives: The objective of this study was to evaluate the survival experience of suspicion COVID-19 hospitalized patients with pneumonia and negative baseline reverse-transcription quantitative polymerase chain reaction (RT-qPCR) test results.
Study design: We conducted a nationwide retrospective cohort study in Mexico.
Methods: Adult pneumonia inpatients fulfilling suspected COVID-19 criteria, and hospital entry from March to August 2020, were enrolled. The Kaplan-Meier method was to use to compare survival estimates among patients with negative RT-qPCR nasopharyngeal or oropharyngeal swabs and those with a baseline positive test.
Results: Data from 64,624 individuals fulfilling suspected COVID-19 criteria were analyzed and 1.6% of them had negative RT-qPCR tests. The overall mortality rate was higher among laboratory-positive patients (48.5% vs. 34.2%, P < 0.001) and, at any given threshold, the survival estimates were higher among RT-qPCR-negative pneumonia inpatients.
Conclusions: The pathogenic mechanism of COVID-19 remains poorly understood and suspected cases with pneumonia and negative laboratory results represent a major challenge for healthcare systems. Our findings suggest that RT-qPCR-negative inpatients may have an improved disease prognosis, but the in-hospital mortality was still high among them. However, further research is needed to clarify the clinical and epidemiological implications of our results.
Keywords: COVID-19; Cohort studies; Prognosis; Reverse transcriptase polymerase chain reaction; Severe acute respiratory syndrome coronavirus 2.
. 2021 May 5;195:123-125.
doi: 10.1016/j.puhe.2021.04.023. Online ahead of print.
Survival in adult pneumonia inpatients fulfilling suspected COVID-19 criteria and baseline negative RT-qPCR
E Murillo-Zamora[SUP] 1 [/SUP], O Mendoza-Cano[SUP] 2 [/SUP], M I Cárdenas-Rojas[SUP] 3 [/SUP], C M Hernandez-Suarez[SUP] 4 [/SUP], J Guzmán-Esquivel[SUP] 5 [/SUP]
Affiliations
- PMID: 34089950
- DOI: 10.1016/j.puhe.2021.04.023
Abstract
Objectives: The objective of this study was to evaluate the survival experience of suspicion COVID-19 hospitalized patients with pneumonia and negative baseline reverse-transcription quantitative polymerase chain reaction (RT-qPCR) test results.
Study design: We conducted a nationwide retrospective cohort study in Mexico.
Methods: Adult pneumonia inpatients fulfilling suspected COVID-19 criteria, and hospital entry from March to August 2020, were enrolled. The Kaplan-Meier method was to use to compare survival estimates among patients with negative RT-qPCR nasopharyngeal or oropharyngeal swabs and those with a baseline positive test.
Results: Data from 64,624 individuals fulfilling suspected COVID-19 criteria were analyzed and 1.6% of them had negative RT-qPCR tests. The overall mortality rate was higher among laboratory-positive patients (48.5% vs. 34.2%, P < 0.001) and, at any given threshold, the survival estimates were higher among RT-qPCR-negative pneumonia inpatients.
Conclusions: The pathogenic mechanism of COVID-19 remains poorly understood and suspected cases with pneumonia and negative laboratory results represent a major challenge for healthcare systems. Our findings suggest that RT-qPCR-negative inpatients may have an improved disease prognosis, but the in-hospital mortality was still high among them. However, further research is needed to clarify the clinical and epidemiological implications of our results.
Keywords: COVID-19; Cohort studies; Prognosis; Reverse transcriptase polymerase chain reaction; Severe acute respiratory syndrome coronavirus 2.