tetano
Editor, Senior Moderator
Psychosom Med
. 2022 Jan 28.
doi: 10.1097/PSY.0000000000001054. Online ahead of print.
Emotional Distress, Targeted Rejection, and Antibody Production Following Influenza Vaccination in Adolescence
Kelsey L Corallo[SUP] 1 [/SUP], Sarah M Lyle, Michael A Carlock, Ted M Ross, Katherine B Ehrlich
Affiliations
Abstract
Objective: The purpose of this study was to explore how both ongoing emotional distress and the experience of a targeted rejection over the past six months are associated with adolescents' antibody response to influenza virus vaccination. We predicted that experiencing a targeted rejection would amplify the hypothesized negative association between emotional distress and antibody response following vaccination.
Methods: Adolescent participants (N = 148) completed two study visits (M days between visits = 27.4, SD = 1.8). At the first visit, they provided blood samples, were administered the seasonal (2018-2019) quadrivalent influenza vaccine (FluzoneTM, Sanofi Pasteur), completed questionnaires, and participated in a semi-structured interview. At the second visit, they provided another blood sample. Hemagglutination-inhibition (HAI) assays were conducted to determine pre- and post-vaccination antibody titers. Targeted rejection experiences were coded from adolescents' interviews.
Results: The Emotional Distress × Targeted Rejection interaction predicted antibody response to the two A strains and the composite of all vaccine strains (bs = -.451 to -.843, ps < .05), but not the two B strains. Results suggested that among adolescents who experienced a targeted rejection over the past six months, emotional distress was negatively associated with vaccine response (however, this finding did not reach statistical significance). Conversely, among adolescents who did not experience a targeted rejection, emotional distress was positively associated with vaccine response (b = 0.173, p = 0.032).
Conclusion: The current study highlights the importance of evaluating both acute life events and ongoing distress as they relate to adaptive immune functioning in adolescence.
. 2022 Jan 28.
doi: 10.1097/PSY.0000000000001054. Online ahead of print.
Emotional Distress, Targeted Rejection, and Antibody Production Following Influenza Vaccination in Adolescence
Kelsey L Corallo[SUP] 1 [/SUP], Sarah M Lyle, Michael A Carlock, Ted M Ross, Katherine B Ehrlich
Affiliations
- PMID: 35100185
- DOI: 10.1097/PSY.0000000000001054
Abstract
Objective: The purpose of this study was to explore how both ongoing emotional distress and the experience of a targeted rejection over the past six months are associated with adolescents' antibody response to influenza virus vaccination. We predicted that experiencing a targeted rejection would amplify the hypothesized negative association between emotional distress and antibody response following vaccination.
Methods: Adolescent participants (N = 148) completed two study visits (M days between visits = 27.4, SD = 1.8). At the first visit, they provided blood samples, were administered the seasonal (2018-2019) quadrivalent influenza vaccine (FluzoneTM, Sanofi Pasteur), completed questionnaires, and participated in a semi-structured interview. At the second visit, they provided another blood sample. Hemagglutination-inhibition (HAI) assays were conducted to determine pre- and post-vaccination antibody titers. Targeted rejection experiences were coded from adolescents' interviews.
Results: The Emotional Distress × Targeted Rejection interaction predicted antibody response to the two A strains and the composite of all vaccine strains (bs = -.451 to -.843, ps < .05), but not the two B strains. Results suggested that among adolescents who experienced a targeted rejection over the past six months, emotional distress was negatively associated with vaccine response (however, this finding did not reach statistical significance). Conversely, among adolescents who did not experience a targeted rejection, emotional distress was positively associated with vaccine response (b = 0.173, p = 0.032).
Conclusion: The current study highlights the importance of evaluating both acute life events and ongoing distress as they relate to adaptive immune functioning in adolescence.