tetano
Editor, Senior Moderator
J Infect Dis. 2014 Feb 3. [Epub ahead of print]
Protective Role of LGP2 in Influenza Virus Pathogenesis.
Si-Tahar M, Blanc F, Furio L, Chopy D, Balloy V, Lafon M, Chignard M, Fiette L, Langa F, Charneau P, Pothlichet J.
Author information
Abstract
Influenza A virus (IAV) triggers a contagious respiratory disease that can cause considerable morbidity and mortality. Using an in vitro approach, we previously demonstrated that the pattern recognition receptor RIG-I plays a key role in IAV-mediated immune response. However, the importance of RIG-I signaling in vivo has not been thoroughly examined because of the lack of an appropriate mouse models. To circumvent this issue, we generated a new transgenic mouse overexpressing LGP2 (LGP2 TG), a major regulator of the RIG-I signaling pathway. The time-course of several parameters was compared in infected WT and LGP2 TG mice. We found that LGP2 TG animals display significantly reduced inflammatory mediators and a lower leukocyte infiltration into the bronchoalveolar airspace. More importantly, mice overexpressing LGP2 had a significant survival advantage. Hence, our in vivo study reveals that LGP2 is a major downregulator of the IAV-triggered detrimental inflammatory response.
PMID:
24493823
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24493823
Protective Role of LGP2 in Influenza Virus Pathogenesis.
Si-Tahar M, Blanc F, Furio L, Chopy D, Balloy V, Lafon M, Chignard M, Fiette L, Langa F, Charneau P, Pothlichet J.
Author information
Abstract
Influenza A virus (IAV) triggers a contagious respiratory disease that can cause considerable morbidity and mortality. Using an in vitro approach, we previously demonstrated that the pattern recognition receptor RIG-I plays a key role in IAV-mediated immune response. However, the importance of RIG-I signaling in vivo has not been thoroughly examined because of the lack of an appropriate mouse models. To circumvent this issue, we generated a new transgenic mouse overexpressing LGP2 (LGP2 TG), a major regulator of the RIG-I signaling pathway. The time-course of several parameters was compared in infected WT and LGP2 TG mice. We found that LGP2 TG animals display significantly reduced inflammatory mediators and a lower leukocyte infiltration into the bronchoalveolar airspace. More importantly, mice overexpressing LGP2 had a significant survival advantage. Hence, our in vivo study reveals that LGP2 is a major downregulator of the IAV-triggered detrimental inflammatory response.
PMID:
24493823
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24493823