tetano
Editor, Senior Moderator
Vaccine. 2018 Jun 7. pii: S0264-410X(18)30818-1. doi: 10.1016/j.vaccine.2018.06.007. [Epub ahead of print]
[h=1]Protection by universal influenza vaccine is mediated by memory CD4 T cells.[/h] Valkenburg SA[SUP]1[/SUP], Li OTW[SUP]2[/SUP], Li A[SUP]1[/SUP], Bull M[SUP]1[/SUP], Waldmann TA[SUP]3[/SUP], Perera LP[SUP]3[/SUP], Peiris M[SUP]2[/SUP], Poon LLM[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] There is a diverse array of influenza viruses which circulate between different species, reassort and drift over time. Current seasonal influenza vaccines are ineffective in controlling these viruses. We have developed a novel universal vaccine which elicits robust T cell responses and protection against diverse influenza viruses in mouse and human models. Vaccine mediated protection was dependent on influenza-specific CD4[SUP]+[/SUP] T cells, whereby depletion of CD4[SUP]+[/SUP] T cells at either vaccination or challenge time points significantly reduced survival in mice. Vaccine memory CD4[SUP]+[/SUP] T cells were needed for early antibody production and CD8[SUP]+[/SUP] T cell recall responses. Furthermore, influenza-specific CD4[SUP]+[/SUP] T cells from vaccination manifested primarily Tfh and Th1 profiles with anti-viral cytokine production. The vaccine boosted H5-specific T cells from human PBMCs, specifically CD4[SUP]+[/SUP] and CD8[SUP]+[/SUP] T effector memory type, ensuring the vaccine was truly universal for its future application. These findings have implications for the development and optimization of T cell activating vaccines for universal immunity against influenza.
[h=4]KEYWORDS:[/h] IL-15; Influenza virus; T cells; Universal vaccine; Vaccinia
PMID: 29887326 DOI: 10.1016/j.vaccine.2018.06.007
[h=1]Protection by universal influenza vaccine is mediated by memory CD4 T cells.[/h] Valkenburg SA[SUP]1[/SUP], Li OTW[SUP]2[/SUP], Li A[SUP]1[/SUP], Bull M[SUP]1[/SUP], Waldmann TA[SUP]3[/SUP], Perera LP[SUP]3[/SUP], Peiris M[SUP]2[/SUP], Poon LLM[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] There is a diverse array of influenza viruses which circulate between different species, reassort and drift over time. Current seasonal influenza vaccines are ineffective in controlling these viruses. We have developed a novel universal vaccine which elicits robust T cell responses and protection against diverse influenza viruses in mouse and human models. Vaccine mediated protection was dependent on influenza-specific CD4[SUP]+[/SUP] T cells, whereby depletion of CD4[SUP]+[/SUP] T cells at either vaccination or challenge time points significantly reduced survival in mice. Vaccine memory CD4[SUP]+[/SUP] T cells were needed for early antibody production and CD8[SUP]+[/SUP] T cell recall responses. Furthermore, influenza-specific CD4[SUP]+[/SUP] T cells from vaccination manifested primarily Tfh and Th1 profiles with anti-viral cytokine production. The vaccine boosted H5-specific T cells from human PBMCs, specifically CD4[SUP]+[/SUP] and CD8[SUP]+[/SUP] T effector memory type, ensuring the vaccine was truly universal for its future application. These findings have implications for the development and optimization of T cell activating vaccines for universal immunity against influenza.
[h=4]KEYWORDS:[/h] IL-15; Influenza virus; T cells; Universal vaccine; Vaccinia
PMID: 29887326 DOI: 10.1016/j.vaccine.2018.06.007