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ProMed: Strain of Q fever in Netherlands may be more virulent

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Senior Moderator
http://www.promedmail.org/pls/otn/f..._BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,80566

Archive Number 20091222.4304
Published Date 22-DEC-2009
Subject PRO/AH/EDR> Q fever - Netherlands (16): pathogenicity, RFI

Q FEVER - NETHERLANDS (16): PATHOGENICITY, REQUEST FOR INFORMATION
***********************************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>

Date: Thu 17 Dec 2009
Source: Radio 1 News [in Dutch, trans. Mod.AS, edited]
<http://www.radio1.nl/contents/11195-nederlandse-q-koorts-bacterie-is-agressiever>


The Q fever bacterium, prevailing in the Netherlands, is unique in
the world. In addition, the Dutch bacterium is possibly more
aggressive than the [Q fever] bacteria prevailing in other countries.
This emerges from research carried out by the Central Veterinary
Institute (CVI) in Lelystad.


--
Communicated by:
ProMED-mail <promed@promedmail.org>

[The above source, kindly provided by a Dutch correspondent, includes
a recorded interview with Hendrik-Jan Roest from the CVI, Lelystad.
Though the wording of the newswire may be somewhat exaggerated by the
reporter, the issue deserves attention. Among other things, Dr Roest
mentions in his interview on-going investigations into the
pathogenicity of the Dutch strain. One of the time-consuming
procedures described by him is the isolation of this intracellular
bacterium in cell culture.

The possibility that the Dutch strain is unique and possibly of
exceptional pathogenicity (to humans? animals?) is of significance;
available results, even preliminary, will be appreciated.


The destruction of infected goat flocks has commenced in south
Netherlands today (Mon 21 Dec 2009). According to Dutch media
reports, the teams will handle about 3 holdings per day, starting
with those farms where the animals are in more advanced pregnancy
(the gestation period in goats is 145-155 days). No activities will
take place during the holidays. In the meantime, another goat flock
in Limburg, south Netherlands has been found infected. The list of
infected farms counts now at 61, with about 40 000 animals to be
destroyed. - Mod.AS]
 
Re: ProMed: Strain of Q fever in Netherlands may be more virulent

http://www.promedmail.org/pls/otn/f..._BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,80574

Archive Number 20091222.4312
Published Date 22-DEC-2009
Subject PRO/AH> Q fever - Netherlands (17): pathogenicity, RFI

Q FEVER - NETHERLANDS (17): PATHOGENICITY, REQUEST FOR INFORMATION
******************************************************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>

Date: Tue 22 Dec 2009
From: Catherine Filejski <Catherine.Filejski@ontario.ca> [edited]


Re: ProMED-mail Q fever - Netherlands (16): pathogenicity, RFI 20091222.4304
----------------------------------------------------------------------
With respect to the request for information about the strain(s) of
_Coxiella burnetii_ causing the Dutch Q Fever outbreak, the US
Centers for Disease Control Emerging Infectious Diseases journal
published a letter from Dutch researchers working in Nijmegen and
Eindhoven in April 2009, reporting some preliminary results from
multiple-locus variable-number tandem repeat analysis (MLVA) typing
of _C. burnetii_ from a variety of human and animal clinical samples
linked to the outbreak obtained from different locations in the Netherlands.

The article (Multigenotype Q Fever Outbreak, the Netherlands by CHW
Klaassen, MH Nabuurs-Franssen, JJHC Tilburg, et al, Emerg Infect Dis.
2009 April; 15(4): 613-4. doi: 10.3201/eid1504.081612) is available at
<http://www.cdc.gov/eid/content/15/4/613.htm>.

The authors reported results showing "that the unprecedented, ongoing
Q fever outbreak in the Netherlands involves multiple genotypes of
_C. burnetii
_. Because most of the genotypes differ only by a single
repeat difference, they might represent microvariants of a
hypervirulent strain that has been introduced in the Dutch animal population."

--
Dr Catherine Filejski, DVM, MA, MEPA, PhD[ABD]
Veterinary Consultant
Enteric, Zoonotic and Vector-Borne Disease Unit
Prevention and Control Section
Public Health Protection and Prevention Branch
Ontario Ministry of Health and Long-Term Care
Toronto, ON M2M 4K5
Canada
<Catherine.Filejski@ontario.ca>

[The authors of the letter to the editor of 'Emerging Infectious
Diseases' above hypothesize that the Dutch strain of _C. burnetii_ is
'hypervirulent'. Experimental evidence for such statement and/or for
the pathogenicity of the strain, as alluded to in ProMED-mail posting
20091222.4304, has yet to be provided. Our request for information is
maintained. - Mod.AS]
 
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