tetano
Editor, Senior Moderator
Trends Microbiol. 2014 Feb 21. pii: S0966-842X(14)00017-1. doi: 10.1016/j.tim.2014.01.005. [Epub ahead of print]
Programmed necrosis in microbial pathogenesis.
Sridharan H1, Upton JW2.
Author information
Abstract
Programmed cell death is an important facet of hostpathogen interactions. Although apoptosis has long been implicated as the major form of programmed cell death in host defense, the past decade has seen the emergence of other forms of regulated death, including programmed necrosis. While the molecular mechanisms of programmed necrosis continue to be unveiled, an increasing number of viral and bacterial pathogens induce this form of death in host cells, with important consequences for infection, control, and pathogenesis. Moreover, pathogen strategies to manipulate or utilize this pathway are now being discovered. In this review, we focus on a variety of viral and bacterial pathogens where a role for programmed necrosis is starting to be appreciated. In particular, we focus on the mechanistic details of how the host or the pathogen might appropriate this pathway for its own benefit.
Copyright ? 2014 Elsevier Ltd. All rights reserved.
KEYWORDS:
Coxsackie B virus, EPEC, Human adenovirus, IRF3, Listeria, MCMV, Mycobacterium, PKR, RIP1, RIP3, Salmonella, TNF, Yersinia, cell death, host defense, influenza, innate immunity, necroptosis, necrosis, reovirus, vaccinia
PMID:
24565922
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24565922
Programmed necrosis in microbial pathogenesis.
Sridharan H1, Upton JW2.
Author information
Abstract
Programmed cell death is an important facet of hostpathogen interactions. Although apoptosis has long been implicated as the major form of programmed cell death in host defense, the past decade has seen the emergence of other forms of regulated death, including programmed necrosis. While the molecular mechanisms of programmed necrosis continue to be unveiled, an increasing number of viral and bacterial pathogens induce this form of death in host cells, with important consequences for infection, control, and pathogenesis. Moreover, pathogen strategies to manipulate or utilize this pathway are now being discovered. In this review, we focus on a variety of viral and bacterial pathogens where a role for programmed necrosis is starting to be appreciated. In particular, we focus on the mechanistic details of how the host or the pathogen might appropriate this pathway for its own benefit.
Copyright ? 2014 Elsevier Ltd. All rights reserved.
KEYWORDS:
Coxsackie B virus, EPEC, Human adenovirus, IRF3, Listeria, MCMV, Mycobacterium, PKR, RIP1, RIP3, Salmonella, TNF, Yersinia, cell death, host defense, influenza, innate immunity, necroptosis, necrosis, reovirus, vaccinia
PMID:
24565922
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24565922