Giuseppe
Emeritus
[Source: Proceedings of the National Academy of the Sciences of the United States of America, full text: (LINK). Extract, edited.]
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The neuraminidase of bat influenza viruses is not a neuraminidase
Adolfo Garc?a-Sastre<SUP>1</SUP>
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Author Affiliations: Department of Microbiology, Department of Medicine, Division of Infectious Diseases, and Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029
Influenza A viruses are classified into subtypes according to their two viral glycoproteins, hemagglutinin (HA) and neuraminidase (NA). These viruses are known to infect multiple animal species, including humans, pigs, horses, dogs, sea mammals, chickens, ducks, and other birds. Although humans are sporadically infected with avian influenza virus strains belonging to multiple subtypes, only H1, H2, and H3 HA subtypes and N1 and N2 NA subtypes have been documented to cause pandemics and annual epidemics of influenza in humans. By contrast, all H16 and N9 subtypes of influenza A viruses are found circulating in birds. The recent discovery of influenza A viruses clearly distinct from any known avian influenza A virus subtype in little yellow-shouldered bats from Guatemala has been the first example of an influenza A virus subtype not found in avian species (1).
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-<SUP></SUP>
Author Affiliations: Department of Microbiology, Department of Medicine, Division of Infectious Diseases, and Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029
Influenza A viruses are classified into subtypes according to their two viral glycoproteins, hemagglutinin (HA) and neuraminidase (NA). These viruses are known to infect multiple animal species, including humans, pigs, horses, dogs, sea mammals, chickens, ducks, and other birds. Although humans are sporadically infected with avian influenza virus strains belonging to multiple subtypes, only H1, H2, and H3 HA subtypes and N1 and N2 NA subtypes have been documented to cause pandemics and annual epidemics of influenza in humans. By contrast, all H16 and N9 subtypes of influenza A viruses are found circulating in birds. The recent discovery of influenza A viruses clearly distinct from any known avian influenza A virus subtype in little yellow-shouldered bats from Guatemala has been the first example of an influenza A virus subtype not found in avian species (1).
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