tetano
Editor, Senior Moderator
Rev Med Virol. 2012 Sep 14. doi: 10.1002/rmv.1729. [Epub ahead of print]
Potential strategies and biosafety protocols used for dual-use research on highly pathogenic influenza viruses.
Du L, Li Y, Gao J, Zhou Y, Jiang S.
Source
Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA.
Abstract
Influenza A viruses (IAVs), particularly the highly pathogenic avian influenza H5N1, have posed a substantial threat to public health worldwide. Although the laboratory generation of the mutant influenza virus H5N1 with airborne transmissibility among mammals, which has been considered as a dual-use research, may benefit the development of effective vaccines and therapeutics against the emerging infectious agents, it may also pose threats to national biosecurity, laboratory biosafety, and/or public health. This review introduces the classification and characterization of IAVs, pinpoints historic pandemics and epidemics caused by IAVs, emphasizes the significance and necessity of biosafety, summarizes currently established biosafety-related protocols for IAV research, and provides potential strategies to improve biosafety protocols for dual-use research on the highly pathogenic avian influenza viruses and other emerging infectious agents. Copyright ? 2012 John Wiley & Sons, Ltd.
Copyright ? 2012 John Wiley & Sons, Ltd.
PMID:
22987727
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22987727
Potential strategies and biosafety protocols used for dual-use research on highly pathogenic influenza viruses.
Du L, Li Y, Gao J, Zhou Y, Jiang S.
Source
Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA.
Abstract
Influenza A viruses (IAVs), particularly the highly pathogenic avian influenza H5N1, have posed a substantial threat to public health worldwide. Although the laboratory generation of the mutant influenza virus H5N1 with airborne transmissibility among mammals, which has been considered as a dual-use research, may benefit the development of effective vaccines and therapeutics against the emerging infectious agents, it may also pose threats to national biosecurity, laboratory biosafety, and/or public health. This review introduces the classification and characterization of IAVs, pinpoints historic pandemics and epidemics caused by IAVs, emphasizes the significance and necessity of biosafety, summarizes currently established biosafety-related protocols for IAV research, and provides potential strategies to improve biosafety protocols for dual-use research on the highly pathogenic avian influenza viruses and other emerging infectious agents. Copyright ? 2012 John Wiley & Sons, Ltd.
Copyright ? 2012 John Wiley & Sons, Ltd.
PMID:
22987727
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22987727