tetano
Editor, Senior Moderator
Mycoses. 2018 Mar 23. doi: 10.1111/myc.12770. [Epub ahead of print]
[h=1]Post-influenzal triazole-resistant aspergillosis following allogeneic stem cell transplantation.[/h] Talento AF[SUP]1,[/SUP][SUP]2[/SUP], Dunne K[SUP]1[/SUP], Murphy N[SUP]2[/SUP], O'Connell B[SUP]2[/SUP], Chan G[SUP]2[/SUP], Joyce EA[SUP]3[/SUP], Hagen F[SUP]4,[/SUP][SUP]5[/SUP], Meis JF[SUP]4,[/SUP][SUP]5[/SUP], Fahy R[SUP]6[/SUP], Bacon L[SUP]7[/SUP], Vandenberge E[SUP]7[/SUP], Rogers TR[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza virus infection is now recognised as a risk factor for invasive pulmonary aspergillosis (IPA). Delays in diagnosis contribute to delayed commencement of antifungal therapy. Additionally, the emergence of resistance to first-line triazole antifungal agents puts emphasis on early detection to prevent adverse outcomes. We present 2 allogeneic stem cell transplant patients who developed IPA due to triazole-resistant Aspergillus fumigatus following influenza infection. We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole-resistance. This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Invasive pulmonary aspergillosis; influenza; stem cell transplant; triazole resistance
PMID: 29570855 DOI: 10.1111/myc.12770
[h=1]Post-influenzal triazole-resistant aspergillosis following allogeneic stem cell transplantation.[/h] Talento AF[SUP]1,[/SUP][SUP]2[/SUP], Dunne K[SUP]1[/SUP], Murphy N[SUP]2[/SUP], O'Connell B[SUP]2[/SUP], Chan G[SUP]2[/SUP], Joyce EA[SUP]3[/SUP], Hagen F[SUP]4,[/SUP][SUP]5[/SUP], Meis JF[SUP]4,[/SUP][SUP]5[/SUP], Fahy R[SUP]6[/SUP], Bacon L[SUP]7[/SUP], Vandenberge E[SUP]7[/SUP], Rogers TR[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza virus infection is now recognised as a risk factor for invasive pulmonary aspergillosis (IPA). Delays in diagnosis contribute to delayed commencement of antifungal therapy. Additionally, the emergence of resistance to first-line triazole antifungal agents puts emphasis on early detection to prevent adverse outcomes. We present 2 allogeneic stem cell transplant patients who developed IPA due to triazole-resistant Aspergillus fumigatus following influenza infection. We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole-resistance. This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Invasive pulmonary aspergillosis; influenza; stem cell transplant; triazole resistance
PMID: 29570855 DOI: 10.1111/myc.12770