tetano
Editor, Senior Moderator
J Virol. 2017 Aug 30. pii: JVI.01164-17. doi: 10.1128/JVI.01164-17. [Epub ahead of print]
[h=1]Population diversity and collective interactions during influenza virus replication and evolution.[/h] Brooke CB[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A virus (IAV) continues to pose an enormous and unpredictable global public health threat, largely due to the continual evolution of escape from pre-existing immunity and the potential for zoonotic emergence. Understanding how the unique genetic make-up and structure of IAV populations influences their transmission and evolution is essential for developing more effective vaccines, therapeutics, and surveillance capabilities. Owing to their mutation-prone replicase and unique genome organization, IAV populations exhibit enormous amounts of diversity both in terms of sequence and functional gene content. Here, I review what is currently known about the genetic and genomic diversity present within IAV populations, and how this diversity may shape the replicative and evolutionary dynamics of these viruses.
Copyright ? 2017 American Society for Microbiology.
PMID: 28855247 DOI: 10.1128/JVI.01164-17
[h=1]Population diversity and collective interactions during influenza virus replication and evolution.[/h] Brooke CB[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A virus (IAV) continues to pose an enormous and unpredictable global public health threat, largely due to the continual evolution of escape from pre-existing immunity and the potential for zoonotic emergence. Understanding how the unique genetic make-up and structure of IAV populations influences their transmission and evolution is essential for developing more effective vaccines, therapeutics, and surveillance capabilities. Owing to their mutation-prone replicase and unique genome organization, IAV populations exhibit enormous amounts of diversity both in terms of sequence and functional gene content. Here, I review what is currently known about the genetic and genomic diversity present within IAV populations, and how this diversity may shape the replicative and evolutionary dynamics of these viruses.
Copyright ? 2017 American Society for Microbiology.
PMID: 28855247 DOI: 10.1128/JVI.01164-17