tetano
Editor, Senior Moderator
PLoS One
. 2020 Nov 5;15(11):e0241535.
doi: 10.1371/journal.pone.0241535. eCollection 2020.
Variant analysis of 1,040 SARS-CoV-2 genomes
Eric C Rouchka[SUP] 1 2 [/SUP], Julia H Chariker[SUP] 2 3 [/SUP], Donghoon Chung[SUP] 4 [/SUP]
Affiliations
Abstract
The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral genome is an RNA virus consisting of approximately 30,000 bases. As part of testing efforts, whole genome sequencing of human isolates has resulted in over 1,600 complete genomes publicly available from GenBank. We have performed a comparative analysis of the sequences, in order to detect common mutations within the population. Analysis of variants occurring within the assembled genomes yields 417 variants occurring in at least 1% of the completed genomes, including 229 within the 5' untranslated region (UTR), 152 within the 3'UTR, 2 within intergenic regions and 34 within coding sequences.
Conflict of interest statement
The authors have declared that no competing interests exist.
. 2020 Nov 5;15(11):e0241535.
doi: 10.1371/journal.pone.0241535. eCollection 2020.
Variant analysis of 1,040 SARS-CoV-2 genomes
Eric C Rouchka[SUP] 1 2 [/SUP], Julia H Chariker[SUP] 2 3 [/SUP], Donghoon Chung[SUP] 4 [/SUP]
Affiliations
- PMID: 33152019
- DOI: 10.1371/journal.pone.0241535
Abstract
The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral genome is an RNA virus consisting of approximately 30,000 bases. As part of testing efforts, whole genome sequencing of human isolates has resulted in over 1,600 complete genomes publicly available from GenBank. We have performed a comparative analysis of the sequences, in order to detect common mutations within the population. Analysis of variants occurring within the assembled genomes yields 417 variants occurring in at least 1% of the completed genomes, including 229 within the 5' untranslated region (UTR), 152 within the 3'UTR, 2 within intergenic regions and 34 within coding sequences.
Conflict of interest statement
The authors have declared that no competing interests exist.