tetano
Editor, Senior Moderator
PLoS One
. 2024 Aug 19;19(8):e0308151.
doi: 10.1371/journal.pone.0308151. eCollection 2024. COVID-19, vaccination and migraine: Causal association or epiphenomenon?
Hailun Jiang[SUP] 1 2 3 [/SUP], Chao Zhang[SUP] 1 3 [/SUP], Xianggang Meng[SUP] 1 3 [/SUP], Shihao Chi[SUP] 1 2 3 [/SUP], Danqi Huang[SUP] 4 [/SUP], Shizhe Deng[SUP] 1 2 3 [/SUP], Guang Tian[SUP] 1 3 [/SUP], Zhihong Meng[SUP] 1 3 [/SUP]
Affiliations
Background: Diverse studies have revealed discrepant evidence concerning the causal association between Corona Virus Disease 2019 (COVID-19) and COVID-19 vaccination in relation to migraines. Investigating the correlation between the former two factors and migraines can facilitate policymakers in the precise formulation of comprehensive post-pandemic interventions while urging the populace to adopt a judicious perspective on COVID-19 vaccination.
Methods: We undertook a Mendelian randomization (MR) study. The primary assessment of the causal relationship between the three different COVID-19 exposures and migraine was conducted using the standard inverse variance weighted (IVW) approach. In the supplementary analysis, we also employed two methodologies: the weighted median estimator (WME) and the MR-Egger regression. Ultimately, the reliability and stability of the outcomes were assessed via Cochran's Q test, the leave-one-out method, the MR-Egger intercept test, and the MR pleiotropy residual sum and outlier (MR-PRESSO) test.
Results: The results indicate an absence of correlation between genetically predicted COVID-19 (①Very severe respiratory confirmed COVID-19: odds ratio [OR], 1.0000881; 95%CI, 0.999748-1.000428; p = 0.6118; ②Hospitalized COVID-19: OR, 1.000024; 95%CI, 0.9994893-1.000559; p = 0.931;③SARS-CoV-2 infection: OR, 1.000358; 95%CI, 0.999023-1.001695; p = 0.5993) and the risk of migraine. Furthermore, the MR-Egger regression and WME also yielded no evidence of COVID-19 elevating the risk of migraine occurrence. Sensitivity analysis affirmed the robustness and consistency of all outcomes.
Conclusions: The results of this study do not offer genetic evidence to substantiate a causal relationship between COVID-19 and migraines. Thus, the deduction drawn from COVID-19 genetic data is that COVID-19 vaccination is unlikely to exert an impact on the occurrence of migraines, though this conclusion warrants further investigation.
. 2024 Aug 19;19(8):e0308151.
doi: 10.1371/journal.pone.0308151. eCollection 2024. COVID-19, vaccination and migraine: Causal association or epiphenomenon?
Hailun Jiang[SUP] 1 2 3 [/SUP], Chao Zhang[SUP] 1 3 [/SUP], Xianggang Meng[SUP] 1 3 [/SUP], Shihao Chi[SUP] 1 2 3 [/SUP], Danqi Huang[SUP] 4 [/SUP], Shizhe Deng[SUP] 1 2 3 [/SUP], Guang Tian[SUP] 1 3 [/SUP], Zhihong Meng[SUP] 1 3 [/SUP]
Affiliations
- PMID: 39159242
- DOI: 10.1371/journal.pone.0308151
Background: Diverse studies have revealed discrepant evidence concerning the causal association between Corona Virus Disease 2019 (COVID-19) and COVID-19 vaccination in relation to migraines. Investigating the correlation between the former two factors and migraines can facilitate policymakers in the precise formulation of comprehensive post-pandemic interventions while urging the populace to adopt a judicious perspective on COVID-19 vaccination.
Methods: We undertook a Mendelian randomization (MR) study. The primary assessment of the causal relationship between the three different COVID-19 exposures and migraine was conducted using the standard inverse variance weighted (IVW) approach. In the supplementary analysis, we also employed two methodologies: the weighted median estimator (WME) and the MR-Egger regression. Ultimately, the reliability and stability of the outcomes were assessed via Cochran's Q test, the leave-one-out method, the MR-Egger intercept test, and the MR pleiotropy residual sum and outlier (MR-PRESSO) test.
Results: The results indicate an absence of correlation between genetically predicted COVID-19 (①Very severe respiratory confirmed COVID-19: odds ratio [OR], 1.0000881; 95%CI, 0.999748-1.000428; p = 0.6118; ②Hospitalized COVID-19: OR, 1.000024; 95%CI, 0.9994893-1.000559; p = 0.931;③SARS-CoV-2 infection: OR, 1.000358; 95%CI, 0.999023-1.001695; p = 0.5993) and the risk of migraine. Furthermore, the MR-Egger regression and WME also yielded no evidence of COVID-19 elevating the risk of migraine occurrence. Sensitivity analysis affirmed the robustness and consistency of all outcomes.
Conclusions: The results of this study do not offer genetic evidence to substantiate a causal relationship between COVID-19 and migraines. Thus, the deduction drawn from COVID-19 genetic data is that COVID-19 vaccination is unlikely to exert an impact on the occurrence of migraines, though this conclusion warrants further investigation.